自拟参芪扶正汤辅助治疗非小细胞肺癌的研究

Study on the Adjuvant Treatment of NSCLC with the Aid of Self-made Shenqifuzheng Decoction

目的:探讨自拟参芪扶正汤辅助化疗对非小细胞肺癌(NSCLC)近期疗效、毒副反应和生存质量的影响。方法:120例晚期NSCLC患者随机分为研究组和对照组,各60例,两组给菌予顺铂+吉西他滨(GP)双周化疗方案,研究组额外再给予自拟中药参芪扶正汤,治疗2个周期。比较两组的近期疗效、毒副反应和生存质量,两组治疗前后的CD4、CD8、CD4/CD8和自然杀伤细胞(NK)的变化。结果:研究组和对照组分别有57例和55例用于最终评价。研究组总缓解率明显高于对照组(P<0.05)。两组生存质量比较差异具有统计学意义(P<0.05)。治疗后,研究组CD4、CD8、CD4/CD8都无明显变化(P>0.05),但NK细胞明显增加(P<0.05);而对照组CD4、CD8、CD4/CD8、NK细胞都有明显变化(P<0.05)。两组治疗后四项指标比较差异均具有统计学意义(P<0.05)。研究组的血小板下降和白细胞下降的发生率都明显低于对照组(P<0.05)。结论:自拟参芪扶正汤辅助化疗能明显提高晚期NSCLC患者的近期疗效、降低毒副反应、提高生存质量、改善免疫功能。

Objective： To investigate the influence of self-made shenqifuzheng Decoction adjuvant chemotherapy for non small cell lung cancer（NSCLC） in the near future curative effect,toxicity and quality of life.Methods：120 cases of patients with advanced NSCLC were randomly divided into study group and control group,60 cases in each.Two groups of bacteria treated with cisplatin plus gemcitabine（GP） biweekly regimen,group of extra to give Chinese herbal compound self-made shenqifuzheng decoction,2 cycles of treatment.The short term efficacy,toxicity and quality of life of the two groups were compared,and the changes of CD4,CD8,CD4/CD8 and natural killer（NK） cells before and after treatment were compared between the two groups.Results： In the study group and the control group,there were 57 cases and 55 cases respectively.The total remission rate of the study group was significantly higher than that of the control group（P〈0.05）.The difference of the quality of life between the two groups was statistically significant（P〈0.05）.After treatment,the study group CD4,CD8,CD4/CD8 were not significantly changed（P〈0.05）,but NK cells significantly increased（P〈0.05）,while the control group CD4,CD8,CD4/CD8,NK cells were significantly changed（P〈0.05）.The two groups after treatment,the differences were statistically significant（P〈0.05）.The incidence of thrombocytopenia and white blood cell decline in the study group was significantly lower than that in the control group（P〈0.05）.Conclusion： Self-made shenqifuzheng decoction combined with chemotherapy can significantly improved the curative effect of patients with advanced NSCLC,reduce the toxic and side effects,improve the quality of life,improve immune function.