标准化肝素抗凝治疗方案在急性心肌梗死溶栓患者中的应用

Application of Standard Unfractionated Heparin Anticoagulant Therapy in Patients with Acute Myocardial Infarction

目的:探讨标准化普通肝素(UFH)治疗方案在急性心肌梗死(AMI)溶栓患者中的应用有效性和可行性。方法:60例AMI溶栓患者,通过阿替普酶100mg溶栓治疗后行UFH抗凝48h,随机分为试验组(A组)和对照组(B组),A组采用标准化肝素治疗方案;B组采用常规经验用药。结果:A组首次测量达标比例、活化部分凝血活酶时间(APTT)≥75s明显高于B组,P<0.01,两组均未见出血并发症患者;A组维持在治疗范围内的时间明显长于,P<0.01。结论:AMI溶栓患者可安全有效应用UFH标准化治疗方案。

Objective： To explore the effectiveness and feasibility of the application of standardized unfractionated heparin（UFH） in patients with acute myocardial infarction（AMI）.Methods： 60 cases of patients with AMI thrombolysis,through O for PU enzyme 100 mg thrombolytic therapy underwent UFH anticoagulation 48 h,randomly divided into the experimental group（group A） and control group（group B）,group A by standard heparin therapy; group B by routine medication.Results： In group a first measurement standard ratio,activated partial thromboplastin time（APTT） is more than or equal to 75 s were significantly higher than that in group B,P〈0.01,two groups had no hemorrhage complications; a group maintain within the range of treatment time was obviously longer than that,P〈0.01.Conclusion： AMI patients with thrombolytic therapy can be safely and effectively used in UFH standardized treatment program.