多重线性回归分析先天性梅毒相关危险因素

Multiple linear regression analysis congenital syphilis related risk factors

目的 研究妊娠梅毒相关的先天性梅毒（CS）危险因素,为预防和控制母一婴梅毒传播提供依据.方法 回顾完成随访妊娠合并梅毒的孕妇138 例,分娩正常儿124 例为对照组,分娩CS 儿14 例进入病例组,运用多重线性回归分析孕妇相关CS 的危险因素.结果 孕妇年龄大、保健周数长、新生儿体重大均是保护性因素,新生儿亲生父母的TRUST 滴度是致病危险因素,而且生父的TRUST 滴度作用大于生母TRUST 滴度的作用.结论 新生儿生父母的TRUST 滴度与CS 高度相关,新生儿生父的预警作用比生母大,他们的血清学筛查在CS 的防控中的意义非常重要.

Objective Studying pregnant syphilis related to congenital syphilis risk factors, to offer evidences to prevent and controlmother-to-child syphilis transmission. Methods Completed follow up 138 pregnant woman infected with syphilis were reviewed, 124 woman deliverednormal baby were control group, 14 woman delivered congenital syphilis baby were case group. Multiple linear regression analysis was applied to studypregnant syphilis related to congenital syphilis risk factors. Results Pregnant woman’s elder age, longer antenatal care weeks and newborn’s weightswere protecting factors. Natural father’s and mother’s Toluidine Red Untreated Serum Test titres were risk factors, and natural father’s Toluidine RedUntreated Serum Test titres were more important than natural mother’s. Conclusions Natural father’s and mother’s Toluidine Red Untreated Serum Testtitres were congenital syphilis related risk factors, natural father’s precaution is bigger than their mother, and natural father’s serology Screening playimportant role in preventing and controlling congenital syphilis.