择期腹腔镜胆囊切除术应用抗生素的随机对照研究

The randomized controlled study of antibiotics in elective laparoscopic cholecystectomy

目的 探讨择期腹腔镜胆囊切除术应用抗生素在围手术期意义.方法 选取了2012 年4 至2015.05 月我院住院部收治性择期腹腔镜胆囊切除术患者620 例患者为研究对象,并随机分成两组,A 组（n=308）麻醉诱导后静脉滴注头孢替安2.0g,术后同剂量连用2 天,B组（312）则不使用任何抗生素.然后对二组患者术后感染及并发症情况进行观察统计.结果 620 例患者均常规完成手术,其中有15 例发生外科感染,A 组有6 例（1.9%）,B 组有9 例（2.8%）,两组差异无统计学意义（p〉0.05）.两组的术后住院时间均在术后2-3 天出院,术后住院时间差异无统计学意义（P〉0.05）;但两组的住院总费用相比差异有统计学意义（P〈0.05）结论 择期腹腔镜胆囊切除术围手术期不使用抗生素并未增加感染率,是安全可行的.

Objective To study the role of antibiotics in perioperative period during elective laparoscopic cholecystectomy. Methods Thisrandomized clinical trial, conducted from April 2012 to May 2015 at The Second Affiliated Hospital of Anhui Medical University, included 308 patients inprophylactic antibiotic group （A group） with Cefotiam Hydrochloride 2.0g IV for two days and 312 in no antibiotic group（B group）. Clinical indicators andsituation after operation were observed and analyzed. Results 620 operations were completed according to routine protocol. There was no siginificantdifference in wound infections among the two groups （P〉0.05）A group 1.9%（6/308） and B group 2.8%（9/312）. Conclusion Elective laparoscopiccholecystectomy without antibiotics is safe and feasible.