比较洛汀新与缬沙坦对老年急性心肌梗死（AMI）患者心功能的影响

Heart function influence comparison of Lotensin and Valsartan in elderly patients with acute myocardialinfarction （AMI）

目的 对比应用洛汀新与缬沙坦对老年急性心肌梗死（AMI）患者进行治疗后,患者心功能的改善情况.方法 采用随机数字表法将入住我院100 例老年急性心肌梗死患者,其中对照组采用缬沙坦进行治疗,实验组采用洛汀新进行治疗,对比研究两组患者经过治疗后的临床效果.结果 两组患者经过治疗后,应用洛汀新治疗的实验组患者总有效率（96.67%）明显高于应用缬沙坦治疗的对照组患者总有效率（70.00%）,实验组患者治疗前后左室射血分数和B 型脑钠肽的变化情况均明显显著于对照组患者.实验组治疗后患者的TC（3.12±0.78）mmol/L、LDL-C（1.48±0.46）mmol/L 显著低于对照组患者的TC（3.94±0.79）mmol/L、LDL-C（2.39±0.94）mmol/L,差异有统计有意义（P 〈0.05）.结论 在治疗老年急性心肌梗死疾病方面,洛汀新与缬沙坦均具有降血脂、通畅血管及保护神经系统的功能,使脑血管疾病致死及致残发生的概率显著降低,提高患者生存质量,但是洛汀新效果较缬沙坦更胜一筹.

Objective To compare cardiac function improvement of Lotensin and Valsartan in the treatment of elderly patients with acutemyocardial infarction （AMI） patients after treatment. Methods using the method of random digits table admitted in our hospital 100 cases of elderlypatients with acute myocardial infarction, the control group was used valsartan treatment, and the experimental group was treated with Lotensin, aftertreatment the clinical effect was compared. Results after treatment, the patients in the experimental group using Lotensin treatment the total effective rate（96.67%） was significantly higher than the application of valsartan treatment in the control group （70%）, and left ventricular ejection fraction and B - typenatriuretic peptide changes before and after treatment of the experimental group was obviously significant better than the control group, the experimentalgroup after treatment TC （3.12 ＋ 0.78） mmol/L, LDL-C （1.48 ＋ 0.46） mmol/L was significantly lower than the control group TC （3.94 ＋ 0.79） mmol/L,LDL-C （2.39 ＋ 0.94） mmol/L, and there was significant difference （P 〈0.05）. Conclusion in the treatment of elderly patients with acute myocardialinfarction, Lotensin and valsartan can reduce lipid, Unobstructed blood vessels and protect the function of the nervous system, the brain vascular diseaseprobability of disability and death occurred significantly reduce, improve the quality of life of patients, but the Lotensin treatment effect is better thanvalsartan.