心复康丸对压力超负荷大鼠心肌肥厚的影响

Effect of Xinfukang Pill on Myocardial Hypertrophy by Pressure Overload in Rats

目的观察心复康丸对压力超负荷性心肌肥厚大鼠超声心动指标及心肌肥厚程度的影响。方法 Wistar雄性大鼠采用腹主动脉缩窄的方法复制心肌肥厚和心室重构的模型。造模4周后,随机分为假手术组(S组)、模型组(M组)、依那普利组(E组)、心复康丸低剂量组(L组)、心复康丸高剂量组(H组)。分别于术后8周、12周采用超声心动评价心功能,并观察心脏肥大指数变化。结果术后8周,M组大鼠出现压力超负荷介导的向心性肥厚,术后12周,M组大鼠心功能进入失代偿期,E组和H组大鼠上述病理性改变均能被抑制;此两组还具有降低心脏肥大指数的作用(P<0.01)。结论心复康丸具有改善超声心动指标,延缓心肌肥厚的作用,并存在一定量效关系。

Objective To explore effect of Xinfukang pill（XFKP）on pressure overload-induced myocardial hypertrophy and echocardiography in rats.Methods The experiment adopts the method of narrowing and contraction the aorta in adult and health Wistar rats,hence establishing the model of animals with myocardial hypertrophy and ventricular remodeling.Four weeks after coarctation of abdominal aorta,the Wistar rats were randomly divided into sham surgery（S group）,model group（M group）,enalapril group（E group）,XFKP low dose group（L group）,XFKP high dose group（H group）.After 8,12 weeks,echocardiographic evaluation of cardiac function and cardiac hypertrophy index were observed.Results After eight weeks,rats in M group appear pressure overload mediated concentric hypertrophy,twelve weeks later,rats in M group appear decompensated cardiac function.But these Pathological changes can be inhibited in group E and H.The cardiac hypertrophy index was reduced significately（P〈0.01）.Conclusion XFKP could improve echocardiographic index and to reduce myocardial hypertrophy,and have a certain dose-effect relationship.