冠心舒通胶囊治疗不稳定心绞痛病人校正QT离散度变化及意义

Changes and Significances on Correcting QT Interval Dispersion in Patients with Unstable Angina Treated with Guanxin Shutong Capsules

目的探讨应用冠心舒通胶囊(GSC)治疗对不稳定心绞痛病人校正QT离散度(c QTd)的影响及其与室性心律失常的关系。方法入选164例冠心病不稳定心绞痛(UAP)病人,UAP病人被随机分成两组,R1组在冠心病常规治疗基础上加用冠心舒通胶囊;R2组未加用冠心舒通胶囊;分别于入院时、治疗后第30天测12导联体表心电图c QTd值,记录入院24 h内及治疗后第30天心律紊乱(VA)的发生情况。比较治疗前后校正QT间期离散度、室性心律失常。结果 1UAP病人治疗前c QTd明显高于正常对照组,治疗后c QTd显著下降(65.95 ms±11.82 ms vs,45.47 ms±11.20 ms P=0.000)。2治疗前UAP病人组间c QTd比较无差异,治疗30 d后两组c QTd均较治疗前显著下降(P<0.01),但R1组下降得更明显(P<0.01)。治疗前后UAP病人组间Lown≥2级比较无统计学意义(P>0.05)。结论冠心舒通胶囊治疗可以明显减小UAP病人心电图c QTd。

Objective To explore the influence of Guanxin Shutong capsules（ GSC） on correcting Q-T interval dispersion in patients with unstable angina（ UAP）,and its relationship with ventricular arrhythmia（ VA）. Methods One hundred and sixty-four patients with UAP and 80 health individuals as controls were enrolled in the study. Patients with UAP were randomly assigned to two treatment subgroups： Group 1 treated by routine treatment and GSC,Group 2 treamted by routine treatment. The c QTd values in 12-lead surface electrocardiogram at hospital admission,30 days after treamtment were measured and calculated. The occurrence of VA within 24 hours of admission and 1 month after treamtment was recorded. The c QTd,VA occurence before and after treamtment were compared. Results At baseline,c QTd was significantly elevated in patients with UAP when compared with control subjects,c QTd was markedly decreased after treatment（ 65. 95 ms ±11. 82 ms vs. 32.84 ms ± 4. 47 ms,P = 0. 000; 45. 47 ms ± 11. 20 ms vs. 65. 95 ms ± 11. 82 ms,P = 0. 000）. After treatment,c QTd decreased significantly in two groups,and group1 declined significantly（P〈0. 01）. Conclusion GSC could reduced the correcting Q-T interval dispersion in patients with UAP.