中重度痔疮采用吻合器痔上黏膜环切术联合硬化剂注射术治疗的临床效果分析

Clinical effect analysis on moderate and severe hemorrhoids patients using the PPH combined with sclerotherapy

目的研究分析中重度痔疮采用吻合器痔上黏膜环切术(PPH)联合硬化剂注射术治疗的临床效果。方法从我院中重度痔疮患者中随机选取172例进行临床研究,并按照痔疮患者治疗方法将其分为治疗组(采用PPH联合硬化剂注射术治疗)和对照组(采用外剥内扎术治疗),各为86例,分析两组患者临床治疗效果及血清炎症因子含量变化情况。结果治疗组患者住院时间、术中出血量、术后镇痛、肛门功能恢复时间、并发症发生率和治疗总有效率分别为:(5.5±2.2)d、(18.7±5.5)ml、3.5%、(6.5±1.6)d、4.7%和95.3%;对照组患者住院时间、术中出血量、术后镇痛、肛门功能恢复时间、并发症发生率和治疗总有效率分别为:(10.7±3.7)d、(34.2±5.7)ml、38.4%、(9.2±1.8)d、25.6%和83.7%;治疗组均优于对照组,差异均有统计学意义(P<0.05)。治疗后,治疗组血清炎症因子肿瘤坏死因子α(TNF-α)和白细胞介素-1(IL-1)分别为:(1.76±0.43)ng/L和(5.62±0.74)ng/L,对照组血清炎症因子TNF-α和IL-1分别为:(3.48±0.72)ng/L和(8.42±0.51)ng/L,治疗组比对照组均明显下降,差异均有统计学意义(P<0.05)。结论 PPH联合硬化剂注射术在治疗中重度痔疮临床上具有良好治疗作用,对中重度痔疮患者临床症状具有显著改善作用。

Objective To research the effect of clinical treatment on moderate and severe hemorrhoids patients by stapling PPH combined curing agent injection. Methods In our hospital 172 patients with moderate to severe hemorrhoids were randomly selected, according to the treatment of hemorrhoids patients were divided into treatment group and control group, each were 86 cases, analyzed the clinical treatment and changes of serum inflammatory factor levels. Results In treatment group, hospitalization time, blood loss, postoperative pain, anal function recovery time, complication rate and total effective rate, were（5.5±2.2）d,（18.7±5.5）ml, 3.5%,（6.5±1.6）d, 4.7% and 95.3%; in the control group were（5.5±2.2）d,（18.7±5.5）ml, 3.5%,（6.5±1.6）d, 4.7% and 95.3%; The treatment group was superior to control group, the difference had statistical significance（P〈0.05）. After treatment, in the treatment group the TNF alpha and IL-1 were（1.76±0.43）ng/L and（5.62±0.74）ng/L, respectively,and the control group were（3.48±0.72）ng/L and（8.42±0.51）ng/L. The treatment group was significantly lower than the control group, the difference had statistical significance（P〈0.05）. Conclusion PPH combined with sclerotherapy surgery in the treatment of severe hemorrhoids has a good effect on the clinical, a kind of clinical symptoms in patients with moderate and severe hemorrhoids have be improved.