足细胞自身抗原在原发性膜性肾病中的研究进展被引量：1

Research progress of podocyte autoantigen in idiopathic membranous nephropathy

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摘要膜性肾病是导致成人肾病综合征的常见病理类型,特征性的病理学改变是肾小球毛细血管袢上皮侧可见大量免疫复合物沉积,其发病机制至今尚未完全明确。近年来研究发现,足细胞蛋白可能是参与膜性肾病的自身抗原,包括足细胞胞膜蛋白中性内切酶、M型磷脂酶A2受体和1型血小板反应蛋白7A域以及足细胞胞质蛋白醛糖还原酶、超氧化物歧化酶2和α-烯醇化酶等。足细胞抗原是重要的分子标记物,为阐明膜性肾病的诊断治疗提供了重要的线索。 Membranous nephropathy is the leading cause of nephrotic syndrome in adults, caused by immune complexes localization in the subepithelial zone of glomerular capillaries. The pathogenetic mechanisms remain incompletely understood. Recent findings indicate that more than one podocyte proteins may act as an autoantigen in human membranous nephropathy. Indentified antigens are membrane proteins, such as neutral endopeptidase and phospholipase A2 receptor, thrombospondin type-1 domain-containing 7A, and components of the cytoplasm, such as aldose reductase, superoxide dismutase, and α-enolase. As important molecular markers, podocyte autoantigens provide an important clue for the diagnosis and treatment of membranous nephropathy.

作者李晓莉

机构地区天津医科大学总医院肾内科

出处《中华临床医师杂志（电子版）》 CAS 2016年第8期135-138,共4页 Chinese Journal of Clinicians(Electronic Edition)

关键词肾小球肾炎膜性足细胞发病机制 Glomerulonephritis membranous Podocytes Pathogenesis

分类号 R692 [医药卫生—泌尿科学]

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参考文献33

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