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新疆某三甲医院汉族、维吾尔族和哈萨克族高血压住院患者发生腔隙性脑梗死危险因素的差异性分析 被引量:3

To analyze the differences of risk factors in hypertensive patients with lacunar infarction among
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摘要 目的探讨新疆汉族、维吾尔族、哈萨克族高血压患者发生腔隙性脑梗死危险因素的差异性。方法回顾性调查2012年1月至2015年5月高血压患者共1 319例,其中男700例,女619例。汉族746例,维吾尔族343例,哈萨克族230例,空腹采血,行动态血压、颈部血管超声等检查,对相关危险因素进行Logistic回归分析。结果汉族腔隙性脑梗死256例,维吾尔族腔隙性脑梗死112例,哈萨克族腔隙性脑梗死96例。汉族、维吾尔族、哈萨克族高血压患者发生腔隙性脑梗死的主要部位依次均为:双侧基底节区、半卵圆中心、放射冠。汉族高血压患者在额叶区腔隙性脑梗死的比例高于维吾尔族、哈萨克族;维吾尔族高血压患者在脑干区腔隙性脑梗死的比例高于汉族、哈萨克族;哈萨克族在放射冠、脑实质区腔隙性脑梗死的比例高于汉族、维吾尔族(P<0.05)。Logistic回归显示:年龄、血清胱抑素C、夜间SBP为汉族高血压患者发生腔隙性脑梗死的独立危险因素。年龄、血清胱抑素C、晨峰SBP、斑块、平均心率为维吾尔族高血压患者发生腔隙性脑梗死的独立危险因素,斑块阳性的维吾尔族高血压患者发生腔隙性脑梗死的风险为斑块阴性的患者的2.613倍。年龄、血清胱抑素C为哈萨克族高血压患者发生腔隙性脑梗死的独立危险因素。结论汉族、维吾尔族、哈萨克族高血压患者在额叶、脑干、放射冠、脑实质腔隙性脑梗死的比例不同,可能与各民族的遗传特质等不同相关。汉族、维吾尔族、哈萨克族高血压患者发生腔隙性脑梗死均与年龄、血清胱抑素C有关,但汉族还与夜间SBP相关,维吾尔族还与晨峰SBP、颈部血管斑块、平均心率相关。 Objective To investigate the differences of hypertensive patients with lacunar infarction of different ethnic groups(Han nationality, Kazak nationality and Uygur nationality in Xinjiang). Methods We investigated 1 319 patients with hypertension from January 2012 to May 2015 in our hospital, 700 were male, 619 female, 746 Han nationality, 343 Uygur nationality, 230 Kazak nationality. We Compared the three nationalities with general data, laboratory examination, differences in ABPP, carotid artery ultrasound and make relevant regression analysis. Results The hypertensive patients with lacunar infarction were 256 Han nationality, 112 Uygur nationality, 96 Kazak nationality. The main parts of three nationalities hypertensive patients occured lacunar infarction in turn were: bilateral basal ganglia region, centrum semiovale, corona radiata. But the lacunar infarction more likely occured in frontal area of Han nationality, in brainstem of Uygur nationality, in corona radiate and brain parenchyma of Kazak nationality(P〈0.05). The Logistic regressions showed: age, Cy C, n SBP was closely related to the occurrence of lacunar infarction in Han nationality. Age, Cy C, SBP in the morning, heart rates, carotid plaques was closely related to the occurrence of lacunar infarction in Uygur hypertensive patients. Uygur hypertensive patients with carotid plaques were 2.613 times to have lacunar infarction than the people without lacunar infarction. Age, Cy C was closely related to the occurrence of lacunar infarction in Kazak hypertensive patients. Conclusion This study shows in the hypertensive patients in Xinjiang, the genetic factors may be related to the percent of lacunar infarction occured in frontal area, brainstem, corona radiate and brain parenchyma are different in the three nationalities. Age, Cy C are closely related to occurrence of lacunar infarction in hypertensive patients of the three nationalities. But Han nationality is also associated with n SBP, Uygur nationality is also associated with SBP in the morning, heart rates and carotid plaques.
出处 《中华临床医师杂志(电子版)》 CAS 2016年第9期13-18,共6页 Chinese Journal of Clinicians(Electronic Edition)
基金 新疆自治区自然科学基金(2014211C028)
关键词 汉族 维吾尔族 哈萨克族 高血压 腔隙性脑梗死 危险因素 Han nationality Uygur nationality Kazak nationality Hypertension Lacunar infarction Risk factor
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