摘要
OBJECTIVE: To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.METHODS: A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux(Q_(tot)), cumulative transmission(T_(tot)), and mean penetration rate(Kp) of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q_(tot)over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.RESULTS: At 1, 2, 4, 6, and 8 h, the Q_(tot),T_(tot)and Kp of pseudoephedrine showed a good correlation with that of amygdalin.CONCLUSION: There was a small difference in theratios of Q_(tot), T_(tot)and Kp between pseudoephedrine and amygdalin, and a correlation between them.
OBJECTIVE： To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.METHODS： A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux（Q_（tot））, cumulative transmission（T_（tot））, and mean penetration rate（Kp） of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q_（tot）over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.RESULTS： At 1, 2, 4, 6, and 8 h, the Q_（tot）,T_（tot）and Kp of pseudoephedrine showed a good correlation with that of amygdalin.CONCLUSION： There was a small difference in theratios of Q_（tot）, T_（tot）and Kp between pseudoephedrine and amygdalin, and a correlation between them.
基金
Supported by the Science and Technology Major Projects for Major New Drugs(Research on innovation of Majiepingchuan effective components cataplasm of transdermal drug delivery system),No.2012ZX09103201-007
