生肌愈疡颗粒联合奥美拉唑对老年性消化性溃疡愈合质量及复发的影响

Effects of Shengjiyuyang Granules Combined with Omeprazole on Healing Quality and Recurrence Rate of Gerontal Peptic Ulcer

目的:观察生肌愈疡颗粒联合奥美拉唑对老年性消化性溃疡愈合质量及复发的影响。方法:选取80例老年性消化性溃疡患者,随机分为观察组与对照组各40例,观察组服用生肌愈疡颗粒加奥美拉唑,对照组单独服用奥美拉唑。两组幽门螺旋杆菌(Hp)阳性者先予三联根除疗法10 d,10 d后服用上述药物开始观察,两组均以6周为1个疗程。疗程结束后复查胃镜,观察Hp根除情况并评价内镜下再生黏膜成熟度及组织学再生黏膜成熟度,治疗6个月和1年后分别观察两组溃疡复发情况。结果:经治疗后,观察组内镜下再生黏膜成熟度Sc期占75.0%,组织学再生黏膜成熟度优级占82.5%,均明显高于对照组42.5%及40.0%;观察组Hp根除率达88.0%,明显高于对照组60.7%,差异有统计学意义(P<0.05)。经治疗1年后,观察组溃疡复发率为5.3%,远低于对照组25.8%,差异有统计学意义(P<0.05)。结论:生肌愈疡颗粒与奥美拉唑联用,能够有效地提高老年性消化性溃疡的愈合质量,降低其复发率,在临床上值得推广。

Objective：To observe t he effects of Shengjiyuyang granules combined with omeprazole on healing quality and recurrence rate of gerontal peptic ulcer.Methods：Eighty elderly patients with peptic ulcer were selected and randomly divided into the observation group（forty patients）and the control group（forty patients）.Patients in the observation group were treated with Shengjiyuyang granules combined with omeprazole,patients in the control group received omeprazole alone.Two groups of patients with helicobacter pylori were first given the triple therapy for 10 days,then,followed with the prescriptive treatment.Two groups of patients were treated six weeks as a course of treatment.Gastroscopy was performed before and after treatment to assess the status of HP eradicating and the endoscopic and histological maturity of regenerated mucosa.Patients with ulcer were followed for 6 months and 1 year to observe the rate of recurrence.Results：After the treatment,the percentage of Sc phase maturity and excellent histological maturity of regenerated mucosa obtained in the observation group was 75.0% and 82.5% respectively,in the control group was 42.5% and 40.0%,there were statistically significant difference（P〈0.05）.The Hp eradication rate in the observation group was 88.0%,significantly higher than that in the control group（60.7%,P〈0.05）.The recurrence rate in one year in the observation group was 5.3%,significantly lower than that in the control group（25.8%,P〈0.05）.Conclusion：Shengjiyuyang granules combined with Omeprazole can improve the healing quality of ulcer and reduce the recurrence rate in the elderly patients,and is worth promoting in clinic.