经鼻蝶入路垂体瘤手术鼻腔并发症处置后的鼻症状评分调查和生活质量分析

Analysis of nasal symptom scores and quality of life questionnaire after treatment of postoperative nasal complications in patients receiving transsphenoidal pituitary adenomas resection

目的对经鼻蝶入路垂体瘤切除术后鼻腔并发症患者予以处置并进行量化考察,对其处置前后的临床症状、生活质量及心理状态进行评分观察,为对其鼻腔并发症处置的有效性及安全性提供理论基础。方法对经鼻蝶入路垂体瘤切除术后鼻腔并发症患者,及时进行鼻科专科处置。并用鼻症状评分在处置前后进行临床症状评分观察,用视觉模拟量表、RQLQ评估量表对其处置前后的生活质量及心理状态进行评估。结果 26例经鼻蝶入路垂体瘤切除患者术后出现鼻腔并发症,均予鼻科专科处置。鼻症状评分、视觉模拟量表处置前后的评分差异具有统计学意义(P<0.01)。RQLQ评估量表处置前后的评分总体差异具有统计学意义(P<0.01),其中日常活动、睡眠、非鼻/眼症状、鼻部症状以及情感反应这5个维度评分差异具有统计学意义(P<0.01),眼部症状、行为问题这2个维度评分差异无统计学意义(P>0.05)。结论对经鼻蝶入路垂体瘤切除术后并发鼻腔并发症者,予以及时鼻科专科处置能显著改善患者的临床症状和生活质量。

Objective To quantitatively investigate the results of clinical symptoms,quality of life（ QOL） and psychological status in the patients with nasal complications after transsphenoidal pituitary adenomas resection via comparing scores pre-and post-disposal of nasal complications,so as to provide theoretical basis of efficacy and safety for the disposal.Methods Rhinologic specialty treatment was given to the patients with nasal complications after transsphenoidal pituitary adenomas resection. Pre-and post-disposal,all the patients received evaluation of clinical symptoms with nasal clinical symptom scoring,assessment of QOL and psychological status with visual analog scale（ VAS） and rhinoconjunctivitis quality of life questionnaire（ RQLQ） assessment scale. Results Nasal complications occurred in 26 cases after transsphenoidal pituitary adenomas resection. The differences of nasal symptom scores and VAS before and after disposal of nasal complications were both statistically significant（ both P〈0. 01）. The differences of total RQLQ and five-dimensions assessment scales including daily activity,sleep,non-nose / eye symptoms,nasal symptoms,and emotional reaction were all statistically significant（ all P〈0. 01）,while those of ocular symptoms,behavioral problems were statistically indifferent（ both P〈0. 05）. Conclusion Timely disposal of the nasal complications after transsphenoidal pituitary adenomas resectioncan significantly improve the patients＇ clinical symptoms and QOL.