血管新生在肿瘤侵袭和器官纤维化中作用的最新认识

The new understanding in functions of angiogenesis in tumor progression and organ fibrosis

微血管密度与肿瘤侵袭力以及器官纤维化程度密不可分,血管新生是这两类疾病的共同靶点。然而,传统抗血管新生疗法由于肿瘤耐药性等原因而疗效有限,而以促血管新生的目标的抗纤维化疗法也因为伴随炎性反应、血管通透性改变等原因陷入瓶颈。本文探讨肿瘤和器官纤维化的在血管新生方面的内在关联。

The microvascular density is significantly associated with tumour metastasis and organ fibrosis, angiogene- sis can be the common target for the therapy of tumor and organ fibrosis. However, traditional anti-angiogenesis strategies attempt to reduce the tumour vascular supply, but their success is restricted by insufficient efficacy or development of resistance. Moreover, the potential angiogenic therapies with the primary aim of ameliorating interstitial fibrosis is falling into bottleneck. Because it is strongly associated with inflammation and changes in vascular permeability. In this review, we will provide a brief review of current understanding of endothelial cell metabolism and vascular niche to understand the underlying relationship between tumor progression and organ fibrosis in angiogenesis.