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高铁环境在血友病骨关节病发病机制中的作用 被引量:4

Iron Excess Environment in the role of Hemophilia bone and Joint Disease Pathogenesis
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摘要 血友病是一组性隐性遗传的出血性疾病,以关节、肌肉、内脏和深部组织出血或轻微外伤后过度出血为特征,其中以关节出血最为常见[1]。反复关节出血导致滑膜增生、慢性滑膜炎、软骨破坏、骨质疏松以及关节间隙狭窄,严重者关节强直、肌肉萎缩出现关节活动受限[2]。
出处 《血栓与止血学》 2016年第2期238-240,共3页 Chinese Journal of Thrombosis and Hemostasis
基金 浙江省中医药优秀青年人才基金资助项目(2015ZQ013)
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  • 1血友病诊断与治疗中国专家共识(2013年版)[J].中华血液学杂志,2013,34(5):461-463. 被引量:119
  • 2DELA CORTE- RODRIGUEZ H, RODRIGUEZ- MERCHAN EC. The current role of orthoses in treating haemophilic arthropathy [ J ]. Hae- mophilia,2015, [ Epub ahead of print ].
  • 3SIMPSON ML, VALENTINO LA. Management of joint bleeding in he- mophilia [ J ]. Expert Rev Hemato1,2012,5 (4) :459-468.
  • 4VAN- MEEGEREN M. Update on pathogenesis of the bleeding joint : an interplay between inflammatory and degenerative pathways [ J ]. Haemophilia ,2010,16 ( 5 ) : 121-123.
  • 5RODRIGUEZ-MERCHAN EC. Orthopaedic problems about the ankle in Hemophilia[ J]. J Foot Ankle Surg,2012,51 (6) :772-776.
  • 6MURATA M,YUDOH K,MASUKO K. The potential roal of vascular endothelial growth factor(VEFG) in cartilage:how the angiogenic fac- tor could be involved in the pathogenesis of osteoarthritis[ J] ? Osteo- arthritis Cartilage ,2008,16 ( 3 ) :279-286.
  • 7VALENTINO LA. Blood-induced joint disease :the pathophysiology of hemophilic arthropathy [ J ]. J Thromb Haemost, 2010,8 ( 9 ) : 1895- 1902.
  • 8LAFEBER FP, MIOSSEC P, VALENTINO LA. Physiopathlolgy of hae- mophilic arthropathy[ J]. Haemophilia,2008,14(4) :3-9.
  • 9OVLISEN K, KRISTENSEN AT, JENSEN AL, et al. IL- 1 b, IL-6, KCand MCP-1 are elevated in synovial fluid from haemophilic mice with experimentally induced haemarthrosis[ J]. Haemophlia ,2009,15 ( 3 ) : 802-810.
  • 10ACHARYA SS,KAPLAN RN,MACDONALD D, et al. Neoangiogene- sis contributes to the development of hemophilic synovitis [ J 1. Blood, 2011,117(8) :2484-2493.

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