维生素D对慢阻肺患者免疫调节功能及生活质量的影响被引量：11

Effect of vitamin D on cellular immune function and quality of life in patients with chronic obstructive pulmonary disease

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摘要目的探讨慢阻肺患者维生素D缺乏情况及对免疫调节功能和生活质量的影响。方法收集慢阻肺患者106例,随机分为治疗组和对照组,每组53例,对照组给予常规一般治疗,治疗组在对照组的基础上添加维生素D3治疗,10万U每次,连用两周;同时于体检科收集60例作为健康对照组,观察慢阻肺患者与健康对照组的维生素D水平的差异,同时观察慢阻肺患者免疫相关指标的变化及CAT评分情况。结果(1)慢阻肺组在治疗前25-(OH)D平均水平比健康对照组显著降低,差异具有统计学意义(P<0.01)。(2)在慢阻肺患者中,治疗组CAT评分显著较对照组低,经比较差异具有统计学意义(P<0.05)。(3)免疫相关指标CD_4^+、CD_8^+、CD_4^+/CD_4^+、Ig A、Ig M、Ig G与治疗前比较,各指标均明显上升,差异具有统计学意义(P<0.05),但治疗组升高明显优于对照组,差异具有统计学意义(P<0.05)。结论慢阻肺患者有较高的维生素D缺乏发病率,添加维生素D辅助治疗,有助于改善慢阻肺患者的免疫调节功能及生活质量。 Objective To investigate the effect of vitamin D on cellular immune function and quality of life in patients with chronic obstructive pulmonary disease. Methods 106 patients combined with chronic obstructive pulmonary disease were divided into the treatment group and the control group randomly, 53 cases in each group. The control group was given conventional treatment, and the treatment group was given the treatment of vitamin D on the basis of the control group. Another 60 healthy people were taken as the control group. The differences of vitamin D and the changes in the related indicators were analyzed. Results （1） Before treatment, the level of 25-（OH）D of the COPD group was significantly higher than that in the control group （P〈0. 01）. （2） The CAT score of the COPD group was significantly higher than that of the control group （ P〈0. 05 ） . （ 3 ） After treatment, the ratio of CD4＋, CD8＋, CD4＋ /CD8＋, IgA, IgM and IgG were higher than before （P〈0. 05）, but they were significantly higher in the treatment group than in the control group （P〈0. 05）. Conclusion There is a higher incidence of vitamin D defi-ciency in patients of COPD, and vitamin D therapy can improve immune function and quality of life in patients with COPD.

作者谭志雄叶洲延傅伟强

机构地区深圳市龙华新区中心医院

出处《临床肺科杂志》 2016年第6期1062-1066,共5页 Journal of Clinical Pulmonary Medicine

关键词慢性阻塞性肺疾病维生素D 生活质量免疫 chronic obstructive pulmonary disease vitamin D quality of life immune function

分类号 R563.9 [医药卫生—呼吸系统]

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