新型纳米靶向给药系统载体材料的设计

Design of Novel Nanocarrier Materials for Targeted Drug Delivery System

新型纳米靶向给药系统的研究与开发对于难治愈性疾病(尤其是肿瘤)的治疗具有重大意义,而其发展很大程度上取决于载体材料的设计。构思巧妙、设计合理的载体材料能使载体实现靶向功能,将药物定位浓集于病灶部位,并最大限度地发挥高效低毒的作用。基于不同的靶向策略,包括被动靶向、主动靶向和响应肿瘤微环境的靶向,综述了近年来一些新型纳米载体材料的设计,为新型纳米靶向给药系统的研究提供参考。

The novel targeted drug delivery system plays an important role in the treatment of refractory and incurable diseases （especially cancer）. Its development to a great extent depends on the design of nanoearrier materials. Nanocarrier materials with intricate and rational design are beneficial to targeting drug to disease site, producing maximum efficacy and minimal side effects. In this review, the design of nnvel nanocarrier materials was reviewed from the perspective of targeting strategies, including passive targeting, active targeting and tnmor microenvironment stimuli-responsive targeting, so as to provide theoretical references for the development of novel targeted drug delivery systems.