2型糖尿病患者检测尿视黄醇结合蛋白和尿微量白蛋白/尿肌酐比值的临床意义

Clinical significance of detection of urinary retinol binding protein and urinary albumin/creatinine ratio in newly diagnosed type 2 diabetic patients

目的探讨初诊2型糖尿病患者检测尿视黄醇结合蛋白(RBP)与尿微量白蛋白/尿肌酐比值(ACR)的临床意义。方法选择本院内分泌病区新诊断的2型糖尿病患者110例为实验组,留取晨尿5 m L,早上空腹采静脉血6 m L。尿液标本分别用免疫比浊法检测尿RBP和尿微量白蛋白(MALB),用酶法检测尿肌酐(UCr);血清标本用酶法检测尿素(Urea),肌酐(SCr);检测均在全自动生化分析仪上进行。根据检测结果计算尿微量白蛋白与尿肌酐比值(ACR),然后分别计算尿RBP和ACR的阳性率。结果与对照组比较,实验组尿RBP,ACR差异有统计学意义(P<0.05),并且尿RBP,ACR的阳性率差异也有统计学意义(P<0.05)。结论部分初诊2型糖尿病患者已有早期肾损伤的发生,检测尿视黄醇结合蛋白(RBP)与尿微量白蛋白/尿肌酐比值(ACR)对早期糖尿病肾病的诊断和预防糖尿病肾病并发症的发生有重要临床意义。

Objective To explore clinical significance of detection of urinary retinol binding protein and urinary albumin/creatinine ratio in newly diagnosed type 2 diabetic patients. Methods A total of 110 new diagnosed type 2 dia- betes patients were selected asan experimental group and investigated for their urinary retinol binding protein （RBP）and uri- nary albumin/creatinine ratio （ACR）.A total of 50 healthy persons were selected as the controls. All the data were statistical- ly analyzed with SPSS13.0. Results In the experimental group,the urinary RBP and ACR had a significant difference compared with those in the control group （P〈 0.05）, and the difference of positive rates of urinary RBP and ACR also had statistical significance （P〈0.05）. Conclusion A part of newly diagnosed patients with type 2 diabetes have early kidney injury, and the urinary RBP and ACRof them have important clinical significance in the diagnosis of early diabetic nephropathy and prevention of diabetic nephropathy complications.