皮肤微生态在特应性皮炎领域的研究进展

The Update Progress of Relationship between Skin Microbiome and Atopic Dermatitis

特应性皮炎(atopic dermatitis,AD)是儿童最常见的慢性、复发性、炎症性、瘙痒性皮肤病,其发病率逐年升高,严重影响患者及家庭成员的生活质量。其发病机制尚未完全明确,但目前公认皮肤屏障功能的损害如皮肤微生态的变化在AD的发生和进展中发挥着复杂的重要作用。近年来宏基因组学的兴起使研究者能更全面和深入地了解皮肤微生态的失衡在AD进展中的重要作用。文中对AD领域皮肤微生态研究以及宏基因组学相关研究等目前热点问题进行了综述。

Atopic dermatitis（ AD） is a chronic,relapsing,and pruritus inflammatory skin disorder most common in children,with drastic impacts on quality of life,the prevalence of which is increasing continuously. The pathogenesis still remains unclear. It is already evident that the dysfunction in the skin barrier especially the shift in skin microbiome plays an complex and important role in the pathogenesis and progression of AD. Theseyears the emerging of metagenomics lead us deeply into the skin microbiome,the microbiome shift or dysbiosis is significant during disease flares. This review will focus on the hotspot topic about the skin microbiome research and metagenomics in the field of AD.