特应性皮炎的变应原特异性免疫治疗被引量：6

Allergen Specific Immunotherapy for Atopic Dermatitis

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摘要特应性皮炎(AD)是一种常见的、与遗传过敏素质有关的瘙痒性皮肤病。变应原,尤其是气传变应原在外源性AD的复发和加重中起着重要作用。变应原特异性免疫治疗(ASIT)是唯一可能改变变应性疾病自然病程的治疗方法,近年来的临床研究显示其在AD的应用可显著改善临床症状、减少对症药物的使用量和皮炎复发的严重程度。文中综述了变应原在AD中的作用、ASIT在AD的临床疗效、不良反应和相关免疫学指标的改变,并对其应用存在的问题进行了探讨。 Atopic dermatitis（ AD） is a common chronic relapsing inflammatory disease. Allergens,especially aeroallergens,have been shown to play important roles in the recurrence and aggravation of cutaneous inflammation of extrinsic AD. Allergen specific immunotherapy（ ASIT） currently represents the only specific treatment which can alter the allergy march and can provide long-lasting amelioration of allergic symptoms. More recent studies have showed that ASIT could lead to clinical improvement of atopic dermatitis and decrease the medicine need. In present paper,we review recent advances of ASIT for AD,including the role allergen in pathogenesis of AD,the clinical efficacy,side effects and immunological changes in AD patients after ASIT.

作者宋志强

机构地区第三军医大学西南医院皮肤科

出处《中国医学文摘（皮肤科学）》 2016年第2期180-183,91,共4页 China Medical Abstracts(Dermatology)

关键词变应原特异性免疫治疗特应性皮炎 Allergen specific immunotherapy Atopic dermatitis

分类号 R758.2 [医药卫生—皮肤病学与性病学] R457.2 [医药卫生—治疗学]

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1Leung DY.New insights into atopic dermatitis ; role of skin barrier and immune dysregulation[J].Allergol lnt,2013,62(2):151-161.
2Bieber T.Atopic dermatitis[J].N Engl J AAed,2008,358(14):1483-1494.
3Ring J,Alomar A,Bieber T,et al.Guidelines for treatment of atopic eczema (atopic dermatitis)Part I[J].J Eur Acad Dermatol Venereol,2012,26(8);1045-1060.
4Ring J,Alomar A,Bieber T,et al.Guidelines for treatment of atopic eczema (atopic dermatitis)Part II[J].J Eur Acad Dermatol Venereol,2012,26(9);1176-1193.
5Leung DY,Boguniewicz M,Howell MD,et al.New insights into atopic dermatitis[J].J Clin Invest,2004,113(5):651-657.
6Novak N,Leung DY.Advances in atopic dermatitis[J].Curr Opin Immunol,2011,23(6):778-783.
7Gavino AC,Needham GR,High WA.Atopic dermatitis,patch testing,and house dust mites:a brief review[J].Dermatitis,2008,19(3):121-128.
8Hostetler SG,Kaffenberger B,Hostetler T,et al.The role of airborne proteins in atopic dermatitis[J].J Clin Aes-thet Dermatol,2010,3(1):22-31.
9Bussmann C,Bockenhoff A,Henke H,et al,Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis[J]. J Allergy Clin Immunol,2006,118(6):1292-1298.
10Akdis M,Akdis CA.Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens[J].J Allergy Clin Immunol,2014,133(3):621-631.