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血浆抗凝血酶Ⅲ和血清降钙素原检测在腹腔感染诊断和预后中的临床价值 被引量:11

Value of Detecting ATⅢ and Serum PCT Levels in Diagnosis and Prognosis of Abdominal Infection
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摘要 目的通过分析腹腔感染患者血浆抗凝血酶Ⅲ(ATm)活性和血清降钙素原(PcT)的水平及相关性,探讨其在腹腔感染诊断和预后中的临床意义。方法选取87例腹腔感染患者和49例健康对照者;根据预后将腹腔感染患者分为预后良好组(69例)和预后不良组(18例);分别检测两组腹腔感染患者及健康对照者的血浆ATⅢ活性和血清PCT水平,并分析其相关性。结果腹腔感染患者血浆ATⅢ活性(70.1%±19.12%)显著低于健康对照者(76.5%±12.0%)(t=-5.823,P〈0.001);血清PCT水平[0.6(0.15~3.37)μg/L]显著高于健康对照者[0.05(0.03~0.06)μg/L](t=5.37,P〈0.001)。在腹腔感染患者中,预后不良组的ATⅢ活性(54.45%±12.24%)显著低于预后良好组(74.14%±18.53%)(t=4.26,P〈0.001);PCT水平E8.4(2.6~41.2)μg/L]显著高于预后良好组[0.29(0.13~1.20)μg/L](P〈0.001)。相关性分析显示,腹腔感染患者血浆ATⅢ活性与血清PCT水平呈显著负相关(r=-0.495,P〈0.001)。结论联合检测血浆ATⅢ和血清PCT水平有助于临床腹腔感染患者的诊断及预后评估。 Objective This study was undertaken to investigate plasma ATⅢ ,PCT levels and relationship of abdominal infection patients,and explore their clinical significance from inflammatory cytokines and coagulation system. Methods AT BI and PCT levels were determined in 87 abdominal infection patients, 49 healthy controls. The correlation analyse were performed. Results The level of AT Ⅲ in abdominal infection patients was (70.1 % ± 19.12 % ) significantly lower than the level in healthy people (76.50% ± 12.0 %, P〈 0. 001). On the contrary, the level of PCT in abdominal infection patients 0.6 (0.15-3.37) was significantly higher than the level in healthy people [0.05(0.03-0.06)μg/L,P〈0. 001]. The level of AT Ⅲ in abdominal infection patients was negatively correlated with the patients PCT, hs-CRP and WBC level (r =- 0. 495,-0. 422,-0. 326,P〈0. 001). Remarkably,the level of ATⅢ of poor prognosis patients (54.45%±12.24%) group was lower than the level of good prognosis patients group good prognosis (74.14 %± 18.53 %, P〈0. 001). And the level of PCT in poor prognosis patients [8.4 (2.6 -41.2)μg/L] was significantly higher than the level in good prognosis patients [-0.29(0.13-1.20)μg/L,P〈0. 001]. In poor prognosis patients group,ATM level significantly negatively correlates with PCT level (r= -0. 519, P〈0. 001). Conclusion In peritoneal cavity infection patients, AT Ⅲ level was well-correlated with PCT and hs-CRP level. The combination of the three indexes detection could contribute to early diagnosis and prognosis evaluation of clinical peritoneal cavity infection.
出处 《现代检验医学杂志》 CAS 2016年第2期22-25,共4页 Journal of Modern Laboratory Medicine
关键词 腹腔感染 抗凝血酶Ⅲ 降钙素原 诊断 预后 abdominal infection AT Ⅲ PCT hs-CRP
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