非小细胞肺癌患者放疗前后血清TSGF和CRP的变化及其临床意义

Impact and Clinical Significance of Radiotherapy on Serum TSGF and CRP in Patients with Non Small Cell Lung Cancer

目的观察非小细胞肺癌（NSCLC）放疗前后血清肿瘤特异性生长因子（TSGF）和C反应蛋白（CRP）的变化，探讨血清TSGF和CRP是否可以用于评价放疗疗效。方法选取124例接受放射治疗的NSCLC病例，分别检测放疗前与放疗后血清TSGF和CRP水平，以P〈0．05为差异具有统计学意义。结果放疗前NSCLC患者血清cRP（8．5±1．1mg／L）及TSGF（110．5±12．8U／ml）水平明显高于健康志愿者（分别为1．7±0．9mg／L和54．7±9．4U／ml）。血清CRP水平在放疗前后差异无统计学意义。放疗后TSGF水平（54．7±9．4U／ml）明显低于放疗前（110．5±12．8U／ml），差异具有统计学意义。放疗有效组患者血清TsGF水平（60．7±8．9U／ml）明显低于无效组（73．5±10．5U／ml），差异具有统计学意义。结论血清TSGF和CRP水平可以用于非NSCLC放疗的疗效评价指标。

Objective To observe the impact of radiotherapy on serum TSGF and CRP levels in patients with non-small cell lung cancer （NSCLC） and investigate whether serum TSGF and CRP levels can evaluate the effect of radiotherapy. Methods 124 cases of NSCLC patients were treated with radiotherapy and tested serum TSGF and CRP levels before and after radiotherapy. P〈0.05 was considered statistically significant. Results Before radiotherapy, serum CRP （8.5 ± 1.1 mg/L） and TSGF levels （110.5± 12.8 U/ml） in NSCLC patients were significantly higher than that in healthy volunteers （1.7 ± 0. 9 mg/L and 54.7±9.4 U/ml）. Serum CRP levels before and after radiotherapy was not statistically significant differences. After radiotherapy,TSGF levels （54.7±9.4 U/ml） were significantly lower than before radiotherapy （110.5± 12.8 U/ml）. TSGF levels in patients with radiotherapy effective group （60.7±8.9 U/ml） were significantly lower than the ineffective group （73.5±10.5 U/ml） ,a statistically significant difference. Conclusion The levels of serum TSGF and CRP can evaluate the effect of radiotherapy in patients with NSCLC.