精神分裂症患者药源性肠梗阻临床分析

Clinical Analysis of Drug-derived Ileus in Patients with Schizophrenia

目的分析住院精神分裂症患者发生药源性肠梗阻的临床特点及危险因素。方法采用回顾性研究,对本院3363例住院精神分裂症患者临床资料进行分析,并对8项观察指标进行单因素和Logistic回归分析。结果 3363例精神分裂症患者中84例(2.50%)发生肠梗阻,Logistic回归分析提示年龄>60岁、住院时间>90天、服用氯氮平、用药时间>5年、服用安坦及腹部手术史是精神分裂症患者肠梗阻的独立危险因素(P<0.05)。结论住院精神分裂症患者合并肠梗阻的危险因素多,临床应根据这些危险因素积极预防。

Objective To analyze the clinical features and risk factors of ileus in patients with schizophrenia, then propose preventive measures. Methods Clinical data were retrospectively reviewed in 3363 hospitalized patients who with schizophrenia. 8 variables were included to statistical analysis using univariate analysis and Logistic regression analysis. Results Among 3363 cases, 84 （ 2, 50 % ） cases were with ileus. Logistic regression analysis showed that patient＇ s age〉60, length of hospital stay〉90d, taking clozapine, treatment time〉5y, taking Antin and a history of abnominal sugury were independent risk factors for ileus in patients with schizophria （P 〈 0.05 ） . Conclusion There are many risk factors in schizophrenia with ileus. To prevent ileus in clinical work, we have to intervene these risk factors early.