COPD合并肺癌的发病机制与治疗进展

Progress in pathogenesis and treatment of COPD combined with lung cancer

COPD是老年人呼吸系统多发疾病，与吸烟有着密切关系。近年来，COPD的发病率仍在不断地上升，现已位居全球人口死亡原因的第4位，据WHO预测，到2030年将升至第3位。肺癌是危害人类健康的常见恶性肿瘤之一，是癌症死亡的首位原因，其发病率与病死率也逐年上升，目前已占全球癌症的12％以上。多年来，人们将COPD和肺癌作为2个独立的疾病进行研究。已有研究显示，在原有。COPD基础上肺癌发病率比一般人群高2．76倍，COPD被视为独立于吸烟之外可以导致肺癌的另一项危险因素。本文将对两者的发病机制和治疗进展作一简要综述。

Chronic obstructive pulmonary disease （COPD） is a common disease among elderly people, which is closely related with smoking. In recent years, COPD ranked the forth major cause of death in the world. Its morbidity is still increasing. According to the latest prediction from WHO, COPD will be the third cause of death in 2030. Lung cancer is one of common malignant tumors with high mortality. The morbidity and mortality of lung cancer are rising year by year, which accounts for more than 12% of all cancers in the world. For many years, these two diseases have been studied seperately. Recent studies have showed the morbidity of lung cancer in COPD patients was 2.76 times higher than that in general population. COPD is an independent risk factor for the etiology of lung cancer besides smoking. The aim of this review is to give a brief introduction of recent progress in the pathogenesis and treatment on COPD combined with lung cancer.