神经炎症调控靶点在帕金森病治疗中的作用

The role of neuroinflammation-related regulatory targets in the treatment for Parkinson's disease

帕金森病(Parkinson’s disease,PD)是一种以多巴胺能神经元退行性病变为主要特征的神经退行性疾病。目前临床上用于治疗PD的药物只能改善疾病的症状,并不能阻止或延缓疾病的进程,因此需要寻找新的分子靶点阻止或延缓多巴胺能神经元的丢失。在PD发展过程中,脑中始终存在着以胶质细胞激活为主要特征的神经炎症反应,越来越多的证据表明神经炎症在PD的发生和发展中起至关重要的作用,大量酶和受体参与神经炎症这一过程。因此本文主要对与神经炎症密切相关的酶和受体作一综述,致力于提供可能阻止或延缓疾病进程的潜在的与炎症相关的治疗靶点。

Parkinson＇s disease（PD） is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons.The present therapeutic drugs for PD can only alleviate the patients＇ symptoms,but cannot prevent or delay progression of the disease.Great efforts have been made in the identification of new molecular targets that can prevent or delay the loss of dopaminergic neurons.Growing evidences support the key role of neuroinflammation in the pathogenesis of PD,featured by the activation of glial cells and many enzymes and receptors.This review will provide an overview of the enzymes and receptors closely related to neuroinflammation,which have a potential in the prevention or treatment of the disease.