波棱内酯Ⅲ:藏药波棱瓜子中分离到的一个新的联芳基七元内酯类化合物

Herpetolide C:one new 7H-dibenzo[c,e]oxepin-5-one from Herpetospermum caudigerum

采用硅胶柱色谱、Sephadex LH-20、半制备HPLC等柱色谱技术,从藏药波棱瓜子中分离得到4个化合物,通过化合物的理化性质和波谱数据鉴定化合物的结构分别为:2,11-dimethoxy-3,9-dihydroxy-7H-dibenzo[c,e]oxepin-5-one(1)、7,8'-didehydroherpetotriol(2)、herpetotriol(3)和kaempferitrin(4)。其中,化合物1为一个新的联芳基七元内酯类化合物,命名为波棱内酯Ⅲ。

The chemical constituents of Herpetospermum caudigerum were investigated using chromatographic methods,including silica gel column chromatography,Sephadex LH-20 and semi-preparative HPLC.Four compounds were isolated and their structures were elucidated by spectral data and physicochemical properties,which were identified as 2,11-dimethoxy-3,9-dihydroxy-7H-dibenzo[c,e]oxepin-5-one（1）,7,8＇-didehydroherpetotriol（2）,herpetotriol（3） and kaempferitrin（4）.Among those,compound 1 is one new 7H-dibenzo[c,e] oxepin-5-one,named as herpetolide C.