期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人免疫缺陷病毒1型(HIV-1)感染者CD4^＋ CD25^＋调节性T细胞的研究进展 被引量：6

下载PDF
导出
摘要 人免疫缺陷病毒1型(HIV-1)感染者常常以自身免疫系统的过度活化为其显著特征,并且HIV疾病进展与自身的免疫活化程度密切相关。调节性T细胞(Treg)在维持机体免疫耐受和免疫应答稳态方面发挥着重要的作用。在HIV-1感染者中,Treg不仅限制机体的过度免疫活化,而且可能抑制针对HIV-1特异的细胞免疫应答;因此,Treg对HIV疾病进展的影响是利是弊,至今尚无定论。对此,深入了解HIV感染者中Treg"量"和"质"的变化及其在HIV感染中的作用,不仅有助于解决目前有关"Treg在HIV病程进展中作用"的争论,而且将有助于设计抗HIV的方案,以期为今后艾滋病的治疗和疫苗的研究提供新的靶点以及提供新的思路和理论参考。
作者 王万海 明亮 阚全程
机构地区 郑州大学第一附属医院检验科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2016年第5期699-702,706,共5页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金委员会-河南人才培养联合基金(U1204811) 中国博士后科学基金(2014T70688) 河南省博士后基金(2012年度) 河南省医学科技攻关计划(201303075,2014030305) 郑州大学第一附属医院青年创新项目(201301)
关键词 人免疫缺陷病毒1型 调节性T细胞 综述
分类号 R512.91 [医药卫生—内科学] R392.12 [医药卫生—免疫学]
  • 相关文献

参考文献35

  • 1Chevalier M F, Weiss L. The split personality of regulatory T cells in HIV infection[J]. Blood, 2013, 121 ( 1 ) : 29 -37.
  • 2Phetsouphanh C, Xu Y, Zaunders J. CIM T cells mediate both positive and negative regulation of the immune response to HIV infection: complex role of T follicular helper cells and regulatory T cells in pathogenesis[J/OL]. Front Immunol, 2015, 5: 681. doi: 10. 3389/fimmu. 2014.00681. eCollection 2014.
  • 3Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the Foxl transcription factor [ J ]. Immunity, 2009, 30 (6) : 899 - 911.
  • 4Cao W, Jamieson B D, Hultin L E, et al. Regulatory T cell expansion and immune activation during untreated HIV type I infection are associated with disease progression [ J ]. AIDS Rcs Hum Retroviruses, 2009, 25(2) : 183 -191.
  • 5Presicce P, Orsbom K, King E, et al. Frequency M circulating regulatoly T cells imamses during chronic HIV infection and is largely controlled by highly active antiretroviral therapy [ J/OL]. PLoS One, 2011, 6(12) : e28118, doi: 10. 1371/journal. pone. 0028118. Epub 2011 Dec 5.
  • 6Rueda C M, Velilla P A, Chouguet C A, et al. Incomplete normalization (ff regulatory T-cell frequency in the gut mucosa of Colombian HIV-infected patients receiving long-term antiretmviral treatment [J/OL]. PLoS One, 2013, 8(8) : e71062, doi: 10. 1371/journal. pone. 0028118. Epub 2011 Dec 5.
  • 7Degaffe G, Zakhour R, Zhang W, et al. Forkhead box protein 3 + regulatory T ceils and Helios + subset in perinatally acquired HIV [J]. Clin Exp Immunol, 2015, 180(1) : 108 -117.
  • 8Zhai R R, Jiang A P, Wang H B, et al. Histamine enhances HIV-1- induced modulation of dendritic cells to skew na'fve T cell differentiation toward regulatory T ceils [ J]. Virology, 2013, 442(2) : 163 -172.
  • 9Singh A, Vajpayee M, Ali S A, et al. Cellular interplay among Thl7, Thl, and Treg cells in HIV-1 subtype " C" infection [ J]. J Med Virol, 2014, 86(3) : 372 -384.
  • 10Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3 + regulatory T cell function[J]. Science, 2008, 322(5899) : 271 - 275.

二级参考文献19

  • 1Pritsker M,Jones P,Blumenthal R. A synthetic all D-amino acid peptide corresponding to the N-terminal sequence of HIV-1 gp41 recognizes the wild-type fusion peptide in the membrane and inhibits HIV-1 envelope glycopretein-mediated cell fusion[J].Proceedings of the National Academy of Sciences(USA),1998,(10):7287-7292.
  • 2Kliger Y,Aharoni A,Rapaport D. Fusion peptides derived from the HIV type 1 glycoprotein 41 associate within phospholipid membranes and inhibit cell-cell fusion.Structure-function study[J].Journal of Biological Chemistry,1997,(13):13496-13505.
  • 3Sempere JM,Soriano V,Benito JM. T regulatory cells and HIV infection[J].Aids Reviews,2007,(01):54-60.
  • 4Kinter A,McNally J,Riggin L. Suppression of HIV-specific T cell activity by lymph node CD25 + regulatory T cells from HIV-infected individuals[J].Proceedings of the National Academy of Sciences(USA),2007,(09):3390-3395.
  • 5Nilsson J,Boasso A,Velilla PA. HIV-1-driven regulatory T-cell accumulation in lymphoid tissuses is associated with disease progression in HIV/AIDS[J].Blood,2006,(12):3808-3817.
  • 6Bloch I,Quintana FJ,Gerber D. T-cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif[J].Federation of America Societies for Experimental Biology Journal,2007,(02):393-401.
  • 7Li X,Hu Y,He L. Icaritin inhibits T cell activation and prolongs skin allograft survival in mice[J].International Journal of Immunopharmacology,2012,(01):1-7.
  • 8Stevenson M. HIV-1 pathogenesis[J].Nature Medicine,2003,(07):853-860.doi:10.1038/nm0703-853.
  • 9Liu S,Jing W,Cheung B. HIV gp41 C-terminal heptad repeat contains mullifunctional domains.Relation to mechanisms of action of anti-HIV peptides[J].Journal of Biological Chemistry,2007,(13):9612-9620.
  • 10Liu S,Wu S,Jiang S. HIV entry inhibitors targeting gp41:from polypeptides to small-molecule compounds[J].Current Pharmaceutical Design,2007,(02):143-162.doi:10.2174/138161207779313722.

共引文献1

同被引文献79

引证文献6

二级引证文献33

细胞与分子免疫学杂志
2016年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部