乙型肝炎病毒基因分型与肝细胞癌发生发展的研究进展

Relationship between hepatitis B virus genotypes and hepatocellular carcinoma

乙型肝炎病毒(hepatitis B virus,HBV)基因分型与抗病毒治疗的反应及肝脏疾病的进展密切相关.本文就HBV的基因分型、地理分布、传播方式及其与肝细胞癌的发生发展作一综述.综合各项研究发现,HBV基因分型与肝细胞癌的临床病理特征有着广泛的联系,其中感染基因型B的患者与大肝癌、多发肿瘤及血管侵犯密切相关.在治疗上,感染HBV基因型A和B的患者对于干扰素的治疗反应较好,但是对于核苷酸类似物,不同的基因型对其反应差异不大.因此,HBV基因分型可以作为病毒基因标志来预测肝细胞癌的发生发展,同时可以帮助医生在临床工作中选择最佳的治疗方案,指导肝癌的预防.

Hepatitis B virus（HBV） genotype is closelyrelated to response to antiviral therapy and the development of liver diseases. In this paper,we will review HBV genotypes, geographic distributions, their modes of transmission, and the occurrence of hepatocellular carcinoma（HCC）. HBV genotypes have extensive connections with clinical pathology of HCC.Genotype B HBV is closely related to largesized HCC, multiple tumors and vascular invasion. Patients with genotypes A or B HBV infection have better responses to interferon therapy, but genotypes seem not to influence the response to nucleotide analogue treatment.Therefore, HBV genotypes can be used as a genetic marker to predict the occurrence of HCC, and help practicing physicians choose optimal anti-viral therapy to prevent the occurrence of HCC.