槲皮素治疗高危型人乳头瘤病毒阳性的宫颈上皮内瘤变患者30例疗效观察

Clinical effects of quercetin in the treatment of 30 patients with high-risk type HPV positive CIN

目的探讨槲皮素治疗高危型人乳头瘤病毒(HPV)阳性感染的宫颈上皮内瘤变I(CINⅠ)患者的临床疗效。方法选取2012年9月至2015年12月就诊于陕西中医药大学第二附属医院妇科门诊高危型HPV阳性的CINⅠ患者90例。按数字表法随机分为3组:治疗组用槲皮素3 g阴道给药;阳性对照组用奥平栓6 g阴道给药;空白对照组常规阴道擦洗。3组均每2 d给药1次,连续2周为1个治疗周期,治疗3个周期。3个月后复查HPV、液基细胞,进行病理检查。结果治疗组高危HPV转阴22例,转阴率73.3%;阳性对照组高危HPV转阴21例,转阴率70.0%;空白对照组高危HPV转阴10例,转阴率33.3%。治疗组和阳性对照组治疗后转阴率高于空白对照组,差异有统计学意义(P<0.05)。治疗组液基细胞转阴28例,转阴率93.3%;阳性对照组液基细胞转阴18例,转阴率60.0%;空白对照组转阴10例,转阴率33.3%。治疗组转阴率显著高于阳性对照组和空白组,差异有统计学意义(P<0.05)。治疗组病检结果转为正常21例,转阴率70.0%;阳性对照组转为正常19例,转阴率63.3%;空白对照组转为正常16例,转阴率53.3%。治疗组和阳性对照组治疗后转阴率高于空白组,差异有统计学意义(P<0.05)。结论槲皮素治疗HPV感染的CINⅠ患者,疗效显著,而且具有一定的抗炎作用。

Objective To investigate the clinical effects of quercetin in the treatment of patients with high-risk type human papillomavirus（ HPV） positive cervical intraepithelial neoplasia（ CIN）. Methods Ninety patients with HPV positive CIN hospitalized in the Outpatient Department of Gynecology,Second Affiliated Hospital,Shanxi Chinese Pharmacological University,from September 2012 to December 2015 were selected for the study. The patients were equally divided into 3 groups： the treatment group,the positive control group and the blank control group. The treatment group received medication of 3 g quercetin by the way of vagina. The positive control group was given 6 g Opin（ plug） also by the way of vagina,and the blank control group had routine cleansing of vagina.The patients of the 3 groups received treatment once every other day,for a succession of 2 weeks,with 2 weeks as a treatment course,and with a total of 3 treatment courses. Three months later,the patients were reexamined on HPV and fluid-based cells,and had pathological examination as well. Results Twenty-two patients with high-risk type HPV in the treatment group turned negative,with the negative-turning rate of 73. 3%,while 21 patients with high-risk type HPV in the positive control group turned negative,with the negative-turning rate of 70. 0%,and 17 patients in the blank control group turned negative,with the negative-turning rate of 33. 3%. Following treatment,the negative-turning rates of the treatment group and the positive control group were higher than that of the negative control group（ P〈0. 05）. With regard to fluid-based cells,28 patients in the treatment group turned negative,with the negative-turning rate of 93. 3%. On the other hand,there were 18 patients in the positive control group that turned negative,with the negative-turning rate of 60. 0%; and there were only 10 patients in the blank control group that turned negative,with the negative-turning rate of33. 3%. The negative-turning rate of the treatment group was significantly higher than those of the positive control group and the blank control group（ P〈0. 05）. With regard to pathological detection results,21 patients in the treatment group turned negative,with the negative-turning rate of 70. 0%,19 patients in the positive control group turned negative,with the negative-turning rate of 63. 3%,while in the blank control group,there were only 16 patients that turned negative,with the negative-turning rate of 53. 3%. The negative-turning rates of the treatment group and the positive control group after treatment were higher than that of the blank control group,and statistical significance could be seen when comparisons were made between them（ P〈0. 05）. Conclusion Quercetin could produce significant therapeutic effects on the CIN patients infected with HPV,and it also turned out to have certain anti-inflammatory effect.