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老年脑梗死认知障碍与尿酸相关性研究 被引量:1

Relationship between uric acid and cognitive impairment in elderly patients with cerebral infarction
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摘要 目的探讨老年脑梗死患者认知障碍的发生率及其与血尿酸的相关性。方法连续收集神经内科老年脑梗死患者102例,根据中文版蒙特利尔认知量表(MoCA)评分分为认知障碍组及非认知障碍组,比较两组尿酸水平及相关因素差异,应用Logistic回归分析评估尿酸与认知障碍的相关性。结果老年脑梗死认知障碍发生率为58.8%(60/102)。认知障碍组血尿酸明显高于非认知障碍组(P〈0.01)。多因素Logistic回归显示校正教育年限、高血压后,高尿酸仍是老年脑梗死患者发生认知障碍的危险因素(OR=1.043,95%CI=1.020~1.067,P〈0.01)。结论老年脑梗死患者急性期具有较高的认知障碍发生率,尿酸是老年脑梗死认知障碍的危险因素。 Objective To investigate the incidence of cognitive impairment and its correlation with uric acid in elderly patients with cerebral infarction.Methods A total of 102 elderly patients with cerebral infarction were selected in clinical practice.Based on the MoCA,all patients were divided into two groups:cognitive impairment group and normal cognitive group.Differences in the uric acid and other related factors were compared between two groups,and logistic regression analysis was used to estimate the correlation between uric acid and cognitive impairment.ResultsThe incidence of cognitive impairment among all 102 patients was 58.8%(60cases).Serum uric acid was significantly higher in cognitive impairment group than in normal group(P 0.01).The multiple logistic regression analysis showed that high uric acid was associated with cognitive impairment(OR =1.043,95%CI1.020-1.067,P 0.01).Conclusion The incidence of cognitive impairment in elderly patients with cerebral infarction was higher,and uric acid was considered the risk factor of cognitive impairment in elderly patients with cerebral infarction.
出处 《临床荟萃》 CAS 2016年第5期536-538,542,共4页 Clinical Focus
关键词 脑梗死 认知障碍 尿酸 brain infarction cognition disorders uric acid
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