丙种球蛋白联合阿司匹林对川崎病合并冠状动脉损伤患者T细胞亚群的影响

Effect of gamma globulin combined with aspirin on T cell subsets in patients with Kawasaki disease with coronary artery lesions

目的探讨丙种球蛋白联合阿司匹林对川崎病合并冠状动脉损伤患者T细胞亚群的影响。方法选取70例川崎病合并冠状动脉损伤患者,按照病床号的奇偶性分为实验组和对照组,每组35例。对照组给予阿司匹林治疗,实验组采用丙种球蛋白联合阿司匹林进行治疗。观察对比两组临床症状消退时间、不良反应发生情况及治疗前后T细胞亚群的变化。结果与对照组比较,实验组发热、淋巴结肿大、黏膜充血、皮疹、手足肿大等症状消退时间均显著缩短,差异有统计学意义(P<0.01)。不良反应发生率实验组为8.57%,对照组为31.43%,二者差异有统计学意义(P=0.037)。治疗前两组T细胞亚群相近,治疗后实验组CD4^+、CD8^+、CD4^+/CD8^+分别为(32.56±2.37)%、(27.62±2.36)%、(1.50±0.09)%,对照组分别为(38.92±2.48)%、(23.28±2.23)%、(2.12±0.18)%,差异均有统计学意义(P<0.05)。结论丙种球蛋白联合阿司匹林治疗川崎病合并冠状动脉损伤患者安全有效,可以显著调节T细胞亚群水平。

Objective To explore the effect of gamma globulin combined with aspirin on T cell subsets in patients with Kawasaki disease with coronary artery lesions. Methods 70 cases of Kawasaki disease with coronary artery lesions in our hospital were divided into experimental group and control group according to the parity of bed number, 35 cases in each group.The control group was given aspirin treatment, and the experimental group was given gamma globulin combined with aspirin.The changes of T cell subsets before and after treatment, clinical symptoms regression time and adverse reactions in two groups were observed and compared. Results In the experimental group, the symptoms of extinction time like Fever, swollen lymph nodes, mucosal congestion, rash, hand, foot swelling, etc were more significantly reduced than those in the control group,and the differences had statistical significance（P〈0.01）. Adverse reaction in the experimental group occurrence rate was8.57%, the control group 31.43%, between which the difference had statistical significance（P=0.037）. Before treatment, T cell subsets of the two groups were similar, and after treatment the experimental group CD4~＋, CD8~＋, CD4~＋/ CD8~＋T cell subsets respectively were（32.56±2.37）%,（27.62±2.36）%, and（1.50±0.09）%, the control group respectively（3.892±2.48）%,（23.28 ±2.23）%, and（2.12 ±0.18）%; the differences had statistical significance between the two groups（P〈0.05）.Conclusion Gamma globulin combined with aspirin in the treatment of Kawasaki disease with coronary artery lesions is safe and effective, which can significantly modulate the levels of T cell subsets.