血清chemerin水平与新疆维吾尔族胆囊结石的相关性研究

The studies between serum chemerin levels and Gallstone disease in Uyghurs

目的探讨chemerin(趋化因子)在肥胖胆囊结石发生中的作用。方法收集2013年-2014年期间在新疆自治区人民医院住院治疗并确诊的维吾尔族胆囊结石患者的血液标本48例;单纯性肥胖组38例;对照组(经B超诊断无胆石症患者,包括腹股沟疝,切口疝及食道裂孔疝患者)共20例。应用ELISA法检测两组对象血清chemerin的浓度,并进行相关统计分析。结果胆囊结石患者TC,TG,HDL,LDL水平与对照组比较,均无差异(P>0.05)。而血清chemerin水平高于对照组(P<0.05)。结论血清chemerin水平升高可能是肥胖促进胆囊结石的发生的原因。

Objective To investigate the role of serum chemerin levels in the formation of gallstone. Methods Serum samples of 48 gallstone patients, 38 obesity patients and 20 control cases were collected,and chemerin levels were determined by enzyme-linked immunosorbent assay（ELISA）. The t-test was used to compare the statistical difference on serum chemerin levels between the two groups.Results There is no statistical difference in the level of TC, TG, HDL and LD between gallstone patients and control group. Serum chemerin level was significantly higher in gallstone patients than that in controls（P〈0.05）. Conclusion the increased level of chemerin may underlied pathogenic mechanism about how obesity promote the formation of gallstone.