慢性阻塞性肺疾病患者医院肺部感染的相关危险因素分析

Analysis of Related Risk Factors of Nosocomial Pulmonary Infections in Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病(COPD)患者医院肺部感染的相关危险因素,以降低医院感染的发生率。方法回顾性分析2012年1月-2014年6月86例肺部感染的COPD患者临床资料,采用单因素和多因素logistic回归分析危险因素。结果单因素分析COPD患者医院发生肺部感染与年龄、住院时间、抗生素使用时间、营养状况、COPD严重程度、是否合并基础疾病、全身糖皮质激素使用时间及有创性操作显著相关(P<0.05),多因素logistic回归分析发现,住院时间、抗生素使用时间、营养状况、COPD严重程度、全身糖皮质激素使用时间是COPD患者肺部感染的独立危险因素(P<0.05)。结论有多种危险因素导致COPD患者医院肺部感染的发生,应积极采取有效措施降低医院肺部感染率。

Objective To investigate the related factors of nosocomial pulmonary infections about chronic obstructive pulmonary disease, and to reduce the incidence of nosocomial infections. Methods Clinical data of 86 COPD patients with nosocomial infections in our hospital from January 2012 to June 2014 were retrospectively analysed, then the univariate analysis and multivariate logistic regression analysis were performed to analyze the risk factors. Results The univariate analysis showed that the incidence of nosocomial pulmonary infections in the COPD patients was significantly related to age, hospitalization duration time, time of antibiotic use, nutrition status, COPD stage, basic diseases, use time of systemic glucocorticoid and invasive operation（P〈0.05）;the multivariate logistic regression analysis indicated that hospita1 ization duration time, antibiotic utilization, nutrition status, COPD stage, use of systemic glucocorticoid and invasive operation were the independent risk factors for the nosocomial pulmonary infections among the COPD patients（P〈0.05）. Conclusion There are a variety of risk factors related to nosocomial pulmonary infections for patients with COPD, effective measures should be taken to reduce the incidence of nosocomial pulmonary infection.