补充锌剂及维生素AD治疗结核性脑膜炎中远期疗效观察

Observation of Long-term Effacasy on Tuberculous Meningitis with Zinc Supplementation and Vitamin AD Treatment

目的观察补充锌剂与维生素AD治疗结核性脑膜炎的中远期临床疗效。方法选择新疆伊犁州新华医院2008年11月至2013年12月期间收治的48例同时接受抗痨序贯治疗和辅助性治疗的结核性脑膜炎患者,配对48例仅接受抗痨序贯治疗的患者作为对照组。辅助治疗为每日补充锌剂与维生素AD,分别于治疗3个月、6个月和18个月时进行随访并记录患者情况。结果观察组和对照组在治疗18个月后各观测指标异常的人数与首次治疗时相比均有明显减少,差异有统计学意义(P<0.05)。但在随访终点两组之间观测指标的异常人数尚无统计学差异。结论传统抗痨治疗的有效性毋庸置疑,在此基础上补充锌剂与维生素AD作为辅助性治疗,可以起到重要的促进及补充作用。

Objective Supplement zinc and vitamin AD long-term clinical curative effect for the treatment of tuberculous meningitis.Methods Select Yili prefecture, Xinhua Hospital of November 2008 to December 2013 in 48 cases during the same time receiving anti-tuberculosis sequential therapy and adjuvant therapy of patients with tuberculous meningitis, 48 cases matched only accept sequential treatment of patients with anti-tuberculosis as a control group. Adjuvant therapy daily zinc supplementation with vitamin AD, respectively in the treatment of three months, six months and were followed up for 18 months and recorded the patient＇s condition. Results The number of observation group and the control group after 18 months of treatment observing abnormalities when compared to the first treatment with significantly reduced, the difference was statistically significant（P〈0.05）. However, between the end of follow-up observations of the two groups no significant difference in the number of abnormalities. Conclusion There is no doubt the effectiveness of traditional anti-tuberculosis treatment, based on zinc supplementation with vitamin AD as an adjuvant therapy, can play an important and complementary role in promoting.