尿蛋白、尿β2-MG及尿IgG在特发性膜性肾病预后意义被引量：3

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摘要特发性膜性肾病（idiopathic membranous nephropathy,IMN）是成人肾病综合征（nephroticsyndrome,NS）最常见的病因[1],近年来,膜性肾病的发病率逐渐增加,而长期的随访研究发现高达30%~50%的患者会在5~10年内进展至终末期肾脏病（end stage renal disease,ESRD）甚至死亡[2-3]。

作者徐丹陆晨

机构地区新疆医科大学新疆自治区人民医院

出处《新疆医学》 2016年第2期227-230,共4页 Xinjiang Medical Journal

基金新疆维吾尔自治区"科技援疆"项目:维吾尔族IgA肾病尿液糖基化蛋白质组学研究(课题编号:2013911114) 新疆维吾尔自治区自然基金课题:C1GALT1 ST6GALNAC2基因交互作用与维吾尔族IgA肾病严重度的关联性研究(课题编号:2012211A088) 新疆维吾尔自治区"十二五"重大科技专项:阿勒泰地区常见病临床路径应用与示范及基层医疗服务标准化建设(专项编号:201230119)

关键词膜性肾病 IgG 尿蛋白终末期肾脏病 MEMBRANOUS 预后意义免疫抑制剂终末期肾病随访研究肾小管间质损害

分类号 R5 [医药卫生—内科学]

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参考文献23

1Beck LH Jr, Salant DJ. Membranous nephropathy; .recent travels and new roads ahead[J]. Kidney Int. 2010 May;77(9) ;765-770.
2Segal PE, Choi MJ. Recent advances and prognosis in idiopathic membranous nephropathy. [J]Adv Chronic Kidney Dis. 2012 Mar; 19(2);114-119.
3Cattran DC. Idiopathic membranous glomernlonephritis[J]. Kidney international. 2001,59(5) ; 1983-1994.
4Ponticelli C, Passerini P. Can prognostic factors assist therapeutic decisions in idiopathic membranous nephropathy? J Nephrol. 2010 Mar-Apr, 23 (2) ; 156-163.
5du Buf-Vereijken PW, Branten AJ, Wetzels JF. Idiopathic mem branous nephropathy; outline and rationale of a treatment strategy [J]. American journal of kidney diseases ; the official journal of the National Kidney Foundation, 2005,46(6) ; 1012-1029.
6Ponticelli C, Passerini P. Management of idiopathic membranous nephropathy[J]. Expert opinion on pharmacotherapy. 2010, 11 (13) ;2163-2175.
7Cattran DC, Pei Y, Greenwood C. Predicting progression in mere branous glomerulonephritis[J]. Nephrology, dialysis, transplanta tion ; official publication of the European Dialysis and Transplant Association - European Renal Association. 1992,7 Suppl 1 ;48-52.
8Troyanov S, Wall CA, Miller JA, et al ; Toronto Glomerulonephri tis Registry Group. Idiopathic membranous nephropathy ; definition and relevance of a partial remission[J].Kidney Int. 2004 Sep; 66 (3) ; 1199-1205.
9Bazzi C, Petrini C, Rizza V, et al.Urinary excretion of IgG and al pha (1)-mieroglobulin predicts clinical course better than extent of proteinuria in membranous nephropathy[J]. American journal of kid hey diseases ; [J]the offlcial journal of the National Kidney Founda tion. 2001,38(2) ;240-248.
10Troyanov S, Wall CA, Miller JA, et al, Toronto Glomerulonephri tis Registry G. Idiopathic membranous nephropathy; definition and relevance of a partial remission[J]. Kidney international. 2004, 66 (3) ; 1199-1205.

二级参考文献29

1王晶,白玉芝,张琴,茹静.β_2-微球蛋白及肾血流动力学变化对老年高血压、2型糖尿病患者早期肾损害的诊断价值[J].中国老年学杂志,2007,27(15):1494-1495. 被引量：26
2Adler S,Salant DJ,Dittmer JE,et al.Mediation of proteinuria in membranous nephropathy due to a planted glomerular antigen[J].Kidney Int,1983,23(6):807 -815.
3Cybulsky AV,Rennke HG,Feintzeig ID,et al.Complementinduced glomerular epithelial cell injury.Role of the membrane attack complex in rat membranous nephropathy[J].J Clin Invest,1986,77(4):1096 -1107.
4Beck LH Jr,Bonegio RG,Lambeau G,et al.M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy[J].N Engl J Med,2009,361(1):11 -21.
5Prunotto M,Carnevali ML,Candiano G,et al.Autoimmunity in membranous nephropathy targets aldose reductase and SOD2[J].J Am Soc Nephrol,2010,21(3):507-519.
6Kuroki A,Shibata T,Honda H,et al.Glomernlar and serum lgG subclasses in diffuse proliferative lupus nephritis,membranous lupus nephritis,and idiopathic membranous nephropathy[J].Intern Med,2002,41 (11):936-942.
7No(e)l LH,Aucouturier P,Monteiro RC,et al.Glomerular and serum immunoglobulin G subclasses in membranous nephropathy and anti-glomerular basement membrane nephritis[J].Clin lmmunol lmmunopathol,1988,46(2):186-194.
8Kuroki A,lyoda M,Shibata T,et al.Th2 cytokines increase and stimulate B cells to produce IgG4 in idiopathic membranous nephropathy[J].Kidney int,2005,68(1):302 -310.
9Kawasaki Y,Suzuki J,Sakai N,et al.Evaluation of T helper-1/-2 balance on the basis of lgG subclasses and serum cytokines in children with glomerulonephritis[J].Am J Kidney Dis,2004,44(1):42 -49.
10Teneer J,Torffvit O,Thysell H,et al.Urine IgG2/lgG4-ratio indicates the significance of the charge selective properties of the glomerular capillary wall for the macromolecular transport in glomerular diseases[J].Nephrol Dial Transplant,1999,14(6):1425-1429.