抗结核固定剂量复合剂不同服药方式的临床效果评价

Study on curative effects of different medication ways with anti-tuberculosis fixed-dose combination

目的评价抗结核固定剂量复合剂不同服药方式治疗新发肺结核的临床效果,为抗结核固定剂量复合剂的临床应用提供科学依据。方法采取每日服药方式（每日组,方案为FDC-2HRZE/4HR）和隔日服药方式（隔日组,方案为FDC-2H3R3Z3E3/4H3R3）治疗新发肺结核患者,对2种不同服药方式的疗效及不良反应进行对比分析。结果治疗第2、6个月末痰菌阴转率每日组和隔日组比较,差异无统计学意义（χ2=0.077、0.378,P均〉0.05）;疗程末X线胸片实变阴影吸收率及空洞阴影改善率每日组与隔日组比较,差异无统计学意义（χ2=0.378、0.207,P均〉0.05）;消化道不良反应发生率每日组和隔日组相比,隔日组大于每日组,差异有统计学意义（χ2=4.623,P〈0.05）。结论隔日服药方式消化道不良反应发生率相对较高,故对于素有胃疾、体质指数偏低、年老及体弱者可考虑采用抗结核FDC每日服药方式治疗。

Objective To explore the curative effects of different treatment way with anti-tuberculosis fixed-dose combination（ FDC） and provide a scientific basis for the clinical application of anti-tuberculosis fixed-dose combination drug. Methods The patients were received treatment with daily treatment way（ Daily group,FDC-2HRZE /4HR） and the alternate day treatment way（ Alternate day group,scheme was FDC-2H3R3Z3E3 /4H3R3）,the efficacy and adverse reactions between the two treatments ways were observed. Results The sputum negative conversion rates after 2,6 months treatment between daily treatment way and every other day treatment way were not statistically significant（ χ2= 0. 077,0. 378,P〉0. 05）. Chest X-ray films consolidation shadow absorption rate and cavity shadow improvement rate between daily treatment way and every other day treatment way were not statistically significant（ χ2= 0. 378,0. 207,P〉0. 05）. The digestive system adverse reactions rate of every other day group was higher than that of daily group,and there was significant difference（ χ2= 4. 623,P〈0. 05）. Conclusion Considering the digestive system adverse reactions were high in every other day treatment way,the aged patients and those who are in poor health and gastrointestinal disorders,low body weight conditions should be treated by using anti-tuberculosis fixed-dose combination in daily treatment way.