临床路径在新生儿ABO血型不合溶血病换血治疗中应用的效果

Application effect of clinical pathway in exchange transfusion therapy for neonatal ABO hemolytic disease

[目的]探讨临床路径在新生儿ABO血型不合溶血病换血治疗中的应用效果。[方法]采用前后对照设计,将临床路径开展后176例ABO血型不合溶血病换血患儿作为观察组,临床路径开展前的164例换血患儿作为对照组,对两组患儿总胆红素换出率、光疗时间、不良反应发生、平均住院日、住院费用、抗菌药物使用率进行比较。[结果]两组患儿的胆红素换出率、光疗时间、不良反应发生率、平均住院日、住院费用、抗菌药物使用率差异均有统计学意义(P<0.05)。[结论]临床路径用于ABO血型不合溶血病换血治疗可提高换血安全性和效果。

Objective：To probe into the application effect of clinical pathway in neonatal ABO exchange transfusion therapy for hemolytic disease.Methods：The before-after control design was used,a total of 176 with ABO hemolytic disease after clinical pathway neonates were selected as the observation group,164 neonates who received the exchange transfusion before clinical pathway were selected as control group.serum total bilirubin replacement rate,time of phototherapy,adverse reactions occurrence,average hospitalization days,hospitalization expenses,the antibiotic use rate of two group were compared.Results：There was statistically significant difference in bilirubin replacement rate,phototherapy time and the incidence of adverse reactions,the average hospitalization days,hospitalization expenses,antibiotic use rate between both groups（P〈0.05）.Conclusion：Clinical pathway for ABO hemolytic disease could improve the efficacy and safety of exchange transfusion.