结直肠癌潜在微生物标记物的研究进展

Advances in the study of potential microbial markers of colorectal cancer

结肠是肠道中细菌含有量最多的部位,也是炎性肠病和癌症的好发部位。肠道微生物群落结构发生变化时可能会引起疾病的发生;然而当结肠发生病变时,肠道微生物群落结构也会发生相应的变化,因此通过分析肠道微生物的变化能预警疾病的发生发展,避免组织病理分析对机体的伤害。本文结合最近的研究成果,从肠道微生物的角度综述了肠道微生物与结直肠癌的关系,列举出一些潜在的能标记结直肠癌的生物标记,为将来用微生物诊断和治疗结直肠癌提供新思路。

The colon is known to be a common site for the development of inflammatory bowel disease and cancer,and the colon also contains a large amount of bacteria.A change in the composition of the intestinal flora can lead to the development of disease,and disease can conversely lead to a change in the composition of the intestinal flora.Therefore,the development and progression of colon disease could be detected by analyzing the intestinal flora,which would avoid the possible harm caused by an invasive histopathologic examination.This review summarizes the results of recent studies that examined the intestinal flora in relation to cancer.This review also summarizes the relationship between intestinal flora and colorectal cancer（CRC）.This review cites potential biomarkers for the early diagnosis of CRC based on a microbial analysis.Hopefully,this review can provide new insights for the non-invasive early diagnosis and treatment of CRC in clinical practice.