萘替芬酮康唑联合他扎罗汀封包治疗角化过度型足癣临床观察

Clinical observation of encapsulation therapy of naftifine ketoconazole combined with tazarotene in the treatment of hyperkeratotic type tinea pedis

目的观察萘替芬酮康唑乳膏联合他扎罗汀乳膏封包治疗角化过度型足癣的临床疗效。方法选择2015年1~12月间我院门诊收治的82例角化过度型足癣患者随机分为两组。观察组予萘替芬酮康唑乳膏和他扎罗汀乳膏外涂患处并封包治疗,对照组仅外涂萘替芬酮康唑乳膏不封包,疗程4周。停药后对两组疗效进行分析对比。结果观察组治疗4周后症状体征评分明显低于对照组,差异有统计学意义（P〈0.05）。观察组患者治疗4周后总有效率达87.8%,对照组患者治疗4周后总有效率达68.3%,差异具有统计学意义（P〈0.05）。真菌清除率观察组达97.6%,对照组为80.5%,差异具有统计学意义（P〈0.05）。观察组1例不良反应未予特殊处理,不影响治疗。结论萘替芬酮康唑乳膏联合他扎罗汀乳膏封包治疗角化过度型足癣的临床疗效显著,不良反应小,值得临床选择应用。

Objective To observe the clinical effects of encapsulation therapy of naftifine ketoconazole cream combined with tazarotene cream in the treatment of hyperkeratotic type tinea pedis. Methods 82 cases of hyperkeratotic type tinea pedis patients who were admitted to our hospital from January 2015 to December 2015, were randomly divided into two groups. The observation group received encapsulation therapy of naftifine ketoconazole cream and tazarotene cream for 4 weeks, and patients in the control group were coated with only naftifine ketoconazole cream without encapsulation for 4 weeks. After withdrawal of medicine, the effects of the two groups were analyzed and compared. Results The signs and symptoms scores of the observation group after 4 weeks of treatment were significantly lower than those of the control group,and the difference was statistically significant（P〈0.05）. After 4 weeks of treatment, the total effective rate of the observation group was 87.8%, and the total effective rate of the control group was 68.3%, and the difference was statistically significant（P〈0.05）. Fungal clearance rate of the observation group was 97.6%, and that of the control group was 80.5%, and the difference was statistically significant（P〈0.05）. There was 1 case of adverse reactions patients in the observation group, and even special treatment was not given, it did not affect the treatment. Conclusion The clinical efficacy of encapsulation therapy of naftifine ketoconazole cream combined with tazarotene cream in the treatment of hyperkeratotic type tinea pedis is significant and worthy of clinical choice and application, with few side effects.