儿童睡眠中癫痫性电持续状态的诊疗进展

The recent progress of electrical status epilepticus during sleep in children

儿童睡眠中癫痫性电持续状态(ESES)是儿童时期一种特殊的脑电图现象,常见于多种癫痫综合征,其中以LKS、ABECTS、CSWS为主。ESES这种持续、异常的癫痫性放电可导致患儿不同程度的神经心理损伤,如认知障碍、学习障碍、精神行为异常等,影响患儿的日常生活质量。本文就近年国内外关于儿童睡眠中癫痫性电持续状态的脑电图表现特点、病因及发病机制、神经心理损伤及相关治疗进展做一综述。

Electrical status epilepticus during sleep （ESES） is a peculiar electroencephalography pattern in children, characterized by paroxysmal activity significantly activated during sleep, typically in the period of NREM （non-rapid eye movement）. ESES is related to various epilepsy syndromes, especially common in landau-Kleffner syndrome, ABECTS, and CSWS, which results in neuropsyehological impairment. This article is aim to review the recent progress in the field of electroencephalogram（EEG）, pathogenesis, neuropsychological impairment, and treatment of ESES.