摘要
The precise control of the conformations of biomolecules adsorbed on a surface at the single-molecule level is significant. However, it remains a huge challenge because of the complex structure and conformation diversity of biomolecules. Herein, a ＂nanopore-confined recognition＂ strategy is proposed to manipulate the adsorption of individual valinomycin molecules at room temperature through precise design of functionalized conjugated macrocycle （CPN8） supramolecular nanopores with complementary architectures and binding sites. We revealed that CPN8 prefers to selectively recognizing valinomycin with complementary architecture because of the strong synergistic interactions between the isopropyl groups of valinomycin and the amino groups of CPN8, with valinomycin- highly oriented pyrolytic graphite （HOPG） interactions. Our perspectives at the single-molecule level will provide valuable insights to improve the design of supramolecular nanopores for conformation-selective recognition of non-conjugated molecules.
The precise control of the conformations of biomolecules adsorbed on a surface at the single-molecule level is significant. However, it remains a huge challenge because of the complex structure and conformation diversity of biomolecules. Herein, a ＂nanopore-confined recognition＂ strategy is proposed to manipulate the adsorption of individual valinomycin molecules at room temperature through precise design of functionalized conjugated macrocycle （CPN8） supramolecular nanopores with complementary architectures and binding sites. We revealed that CPN8 prefers to selectively recognizing valinomycin with complementary architecture because of the strong synergistic interactions between the isopropyl groups of valinomycin and the amino groups of CPN8, with valinomycin- highly oriented pyrolytic graphite （HOPG） interactions. Our perspectives at the single-molecule level will provide valuable insights to improve the design of supramolecular nanopores for conformation-selective recognition of non-conjugated molecules.
基金
Acknowledgements The authors gratefully acknowledged Prof. Chen Wang （National Center for Nanoscience and Technology, China） and Prof. Guocong Guo （Fujian Institute of Research on the Structure of Matter, CAS） for their helpful discussions and advice. This work was supported by the National Basic Research Program of China （No. 2012CB933001）, the National Natural Science Foundation of China （Nos. 51173031, 21472029, 21303202, and 91127043）, the program of Chinese Academy of Sciences （No. YZ201318）, and the Open Project of State Key Laboratory of Supramolecular Structure and Materials （No. sklssm201607）.
