期刊文献+

磁敏感序列成像联合磁共振波谱技术对首发抑郁症海马区静脉变化及细胞代谢的研究 被引量:2

Research of veins change and cell metabolism in bilateral hippocampus regions in first episode depression by combining SWI with ~1H-MRS
下载PDF
导出
摘要 目的联合磁敏感序列成像(SWI)及磁共振波谱(1H-MRS)技术研究首发抑郁症患者海马区静脉及海马区细胞代谢变化之间的关系。方法对2013年10月至2015年10月该院收治的20例首发抑郁症患者(首发抑郁组)及来自医院职工或其家属的20例健康志愿者(健康组)分别采用SWI及1H-MRS序列进行扫描,检测双侧海马区引流静脉的最大直径、长度、分支数目及各代谢指标[包括谷氨酰胺复合物(Glx)、乙酰天门冬氨酸盐(NAA)、胆碱(Cho)、肌酐(Cr)、肌醇(MI)],并将引流静脉变化与细胞代谢水平进行相关性分析。结果首发抑郁组患者左侧脑室下静脉的最大直径较健康组变窄,差异有统计学意义(P<0.05),而长度及分支较健康组增高,但差异均无统计学意义(P>0.05);右侧脑室下静脉的最大直径较健康组变窄,差异有统计学意义(P<0.05),长度及分支较健康组未见明显变化,差异均无统计学意义(P>0.05)。与健康组比较,首发抑郁组患者左侧海马区的Glx/Cr及NAA/Cr下降,而Cho/Cr升高,差异均有统计学意义(t=2.69、2.81、2.36,P<0.05),MI/Cr变化不明显,差异无统计学意义(t=1.19,P>0.05);右侧海马区仅出现Glx/Cr下降,差异有统计学意义(t=2.43,P<0.05)。左侧脑室下静脉的最大直径与左侧海马区的Cho/Cr水平呈明显负相关(r=-0.631,P<0.05),与左侧海马区的Glx/Cr、NAA/Cr及MI/Cr水平呈明显正相关(r=0.568、0.594、0.095,P<0.05)。结论首发抑郁症患者海马区的引流静脉出现形态上的变化,这些变化影响了双侧海马区的神经细胞代谢,可能是首发抑郁症发病机制的一种潜在因素。 Objective To combine SWI with1H-MRS for exploring the relationship of veins and nerve cells metabolism changes of the bilateral hippocampus regions in the patients with first episode depression. Methods The subsequence of SWI and1H-MRS was adopted to scan 20 patients with first episode depression(first episode depression group) and 20 healthy volunteers from the hospital staff or their family members(health group) in our hospital from October 2013 to October 2015 for detecting maximum diameter,length and branch numbers of the bilateral hippocampus draining veins and multiple metabolic indices(Glx,NAA,Cho,Cr and MI)of the bilateral hippocampus,finally,analyzing the correlation between them. Results Compared with the health group,the maximum diameter of left inferior ventricular vein in the first episode depression group became narrow with sta tistical difference(P〈0.05),while the length and branch numbers were increased,but without statistically significant difference(P〈0.05);the maximum diameter of right inferior ventricular vein became narrow compared with the health group,the difference was statistically significant(P〈0.05),while the length and branch numbers had unobvious change without statistical difference(P〈0.05). Compared with the health group,the values of Glx/Cr and NAA/Cr of left hippocampus in the first episode depression group were reduced,while the value of Cho/Cr was increased,the differences were statistically significant(t=2.69,2.81,2.36,P〈0.05),while the value of MI/Cr had no obvious change,the differences were statistically significant(t=1.19,P〈0.05);only the value of Glx/Cr in right hippocampus was reduced with statistical difference(t=2.43,P〈0.05). The maximum diameter of left inferior ventricular vein was negatively correlated to the value of Cho/Cr and positively correlated to the value of Glx/Cr,NAA/Cr and MI/Cr in left hippocampus(r=0.568,0.594,0.095,P〈0.05). Conclusion The morphological change of draining veins in hippocampus appears in the patients with first episode depression,these changes affect the nerve cell metabolism of the bilateral hippocampus,which may be one of the potential factors of first episode depression pathogenesis.
出处 《现代医药卫生》 2016年第9期1292-1295,共4页 Journal of Modern Medicine & Health
基金 江苏大学临床医学专项基金资助项目(JDLC2X002)
关键词 磁共振成像 磁共振波谱学 序列分析 抑郁症 海马 侧脑室 Magnetic resonance imaging Magnetic resonance spectroscopy Sequence analysis Depressive disorder Hippocampus Lateral ventricles
  • 相关文献

参考文献11

  • 1Frodl T, Scheuerecker J,Schoepf V, et al. Different effects of mirtazapine and venlafaxine on brain activation : an open randomized controlled fMRI study[J]. J Clin Psychiatry, 2011 , 72 (4) :448-457.
  • 2王冬青,朱彦,李月峰,李国海,刘珺,朱颖,殷瑞根,吴琴,罗一烽,赵亮,张礼荣.首发抑郁症患者敏感脑结构的磁共振质子波谱分析[J].中华行为医学与脑科学杂志,2011,20(1):19-21. 被引量:31
  • 3Nouretdinov I, Costafreda SG, Gammerman A, et al. Machine learning classification with confidence:application of transductive conformal pre- dictors to MRI-based diagnostic and prognostic markers in depression[J]. Neuroimage, 2011,56 (2) : 809-813.
  • 4Wu HH ,Wang S. Strain differences in the chronic mild stress animal modelof depression[J]. Behav Brain Res,2010,213(1 ) :94-102. .
  • 5王冬青,李月峰,罗一烽,吴琴,殷瑞根,赵亮,许云飞,盛良驹,赵天,刘文,王峥超,孙维斌.抑郁症患者杏仁核、海马形态功能变化的MR研究[J].中华放射学杂志,2011,45(7):623-627. 被引量:22
  • 6Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression[J]. Biol Psychiatry, 2010,67 ( 5 ) : 446-457.
  • 7Sedlacik J, Helm K, Rauscher A, et al. Investigations on the effect of caf- feine on cerebral venous vessel contrast by using susceptibility-weighted imaging(SWI) at 1.5, 3 and 7 T[J]. Neuroimage,2008,40(1 ) : 11-18.
  • 8Pruijm M, Hofmann L, Zanchi A,et al. Blockade of the renin-angiotensin system and renal tissue oxygenation as measured with BOLD-MRI in pa- tients with type 2 diabetes[J]. Diabetes Res Clin Pract, 2013,99 (2) : 136- 144.
  • 9张朝辉,宋景贵.卒中后抑郁单胺类递质与睡眠的研究[J].中风与神经疾病杂志,2008,25(2):188-190. 被引量:20
  • 10Einvik G, Vistnes M, Hrubos-Strm I-I, et al. Circulating cytokine concen- trations are not associated with major depressive disorder in a community- based cohort[J]. Gen Hosp Psychiatry, 2012,34 (3) :262-267.

二级参考文献29

  • 1吴卫文,顾青,黄屏娟,姚景莉.卒中后急性期抑郁状态的相关因素临床分析[J].中风与神经疾病杂志,2005,22(4):356-358. 被引量:37
  • 2林铮,李惠春,龚向阳,卢蕴容,俞少华,禹华良,陈巧珍.抑郁症患者前额叶、海马磁共振质子波谱成像的研究[J].中华精神科杂志,2005,38(4):193-197. 被引量:41
  • 3于法彦,周增杰,刘欣,张凤西,王玉凤,刘红军,丁业庆.脑血管病后精神障碍临床研究[J].脑与神经疾病杂志,1996,4(1):15-17. 被引量:15
  • 4Takahashi T, Yiicel M, Lorenzetti V,et al. An MRI study of the superior temporal subregions in patients with current and past major depression. Prog Neuropsychopharrnacol Biol Psychiatry, 2010,34:98-103.
  • 5Savitz J, Drevets WC. Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev ,2009,33:699-771.
  • 6Brabec J, Rulseh A, Hoyt B, et al. Volumetry of the human amygdala : an anatomical study. Psychiatry Res,2010,182:67-72.
  • 7Malykhin NV, Bouchard TP, Ogilvie CJ, et al. Three-dimensional volumetric analysis and reconstruction of amygdala and hippocampal head, body and taii. Psychiatry Res, 2007, 155: 155-165.
  • 8Velakoulis D, Wood SJ, Wong MT, et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry, 2006,63 : 139-149.
  • 9Savitz J, Nugent AC, Bogers W, et al. Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3 T MRI: the impact of medication. Neuroimage,2010, 49:2966-2976.
  • 10Kronenberg G, Tebartz van Elst L, Regen F, et al. Reduced amygdala volume in newly admitted psychiatric in-patients with unipolar major depression. J Psychiatr Res,2009,43 : 1112-1117.

共引文献68

同被引文献35

引证文献2

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部