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咪达唑仑对冠状动脉旁路移植术术后患者循环和脑氧合功能的影响 被引量:2

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摘要 目的探究咪达唑仑对冠脉搭桥手术术后患者循环、脑氧合功能的影响,比较两种咪达唑仑(多美康和力月西)的作用效果。方法选取体外循环下冠脉搭桥手术的患者40例,随机分为多美康组(D组)和力月西组(L组),每组静脉注射负荷剂量为0.03 mg/kg,维持剂量0.04 mg·kg-1·h-1。采用Philips V24E多功能检测仪监测患者的平均动脉压(MAP)、心率(HR),Swan-ganz导管技术监测患者血流动力学的改变,并计算心输出量(CO)、心脏指数(CI)和体循环阻力(SVR),ES-1000SPM多普勒测量颈内动脉血流,并于颈内静脉和桡动脉取血液标本2 ml进行血红蛋白(Hb)检测和血气分析,计算脑氧耗(CMRO2)。结果与用药前相比,L组患者在30 min时的心输出量、心脏指数显著下降(P<0.05),60 min时CMRO2明显下降(P<0.05)。D组心输出量、心脏指数和CMRO2较L组相比下降速度慢,至90 min时差异无统计学意义(P>0.05)。结论两种咪达唑仑对冠脉搭桥手术患者均有良好地镇静效果,且其对心血管影响较小,可降低脑氧耗。
出处 《河北医药》 CAS 2016年第9期1321-1323,共3页 Hebei Medical Journal
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