转录因子Klfs家族影响肝细胞癌发生发展的机制研究进展

Mechanism of transcription factors KLFs in the occurrence and development of HCC

肝细胞癌(hepatocellular carcinoma,HCC)是我国常见的恶性肿瘤之一,死亡率高,其发生与发展的具体分子机制尚不明确。Krüppel样因子家族(Klfs)是具有锌指结构的高度保守的转录因子家族,共包括17个家族成员。近年来,关于Klfs与肝癌发病机制的研究不断深入,发现Klf2、Klf4、Klf5等家族成员参与肝癌细胞的增殖、分化和浸润转移等过程。本文就Klfs家族成员的功能以及在肝癌发生发展中的作用机制进行综述。

Hepatocellular carcinoma（HCC） is one of the most lethal human cancers in China.The specific molecular mechanism of its occurrence and development is unclear.Krüppel-like factor family（KLF）,which includes 17 members,is a highly conserved transcription factor family with zinc finger structure.The mechanism of KLFs and the pathogenesis of HCC have been studied in recent years.Research revealed that KLF2,KLF4,KLF5,and other KLF family members could be involved in the progression of proliferation,differentiation,invasion,and metastasis of HCC.This review summarizes the function and the mechanism of transcription factors KLF in the occurrence and development of HCC.