加用安心颗粒治疗慢性心力衰竭临床观察

Clinical Observation on Treatment of Anxin Granules for Chronic Heart Failure

目的:观察加用安心颗粒治疗慢性心力衰竭患者的临床疗效。方法:将60例慢性心力衰竭患者随机分为两组各30例,两组患者均根据病情给予硝酸酯类、血管紧张素转换酶抑制剂、洋地黄类、利尿剂、β受体阻滞剂等药物治疗,治疗组同时加用安心颗粒(由人参、桂枝、茯苓、瓜蒌壳、水蛭组成)口服,两组疗程均为28天,观察两组患者治疗前后的临床症状及体征、心功能参数、NT-proBNP含量及安全性等指标。结果:治疗组中医证候疗效总有效率为86.67%,对照组为80.0%,治疗组疗效优于对照组(P<0.05);治疗后Lee氏心衰计分治疗组优于对照组(P<0.05);两组治疗后LVSD值明显降低,LVEF值明显升高,治疗组LVSD值降低与LVEF值升高较对照组明显(P<0.05);两组治疗后NT-pro BNP含量较治疗前明显降低(P<0.05或P<0.01),治疗组优于对照组(P<0.05)。结论:安心颗粒是治疗慢性心力衰竭安全有效的方药。

Objective： To observe the effect of An xin Granules on clinical efficacy for patients suffering from chronic heart failure. Methods： 60 patients suffering from chronic heart failure were randomly divided into 2 groups（n=30 each）. Both groups were treated with medication such as nitrates,angiotensin converting enzyme inhibitors,digitalis,diuretics,β-blockers for 28 days. The therapeutic group was added with Anxin granule. The index of clinical symptoms,signs,cardio functional parameters,NT-proBNP and safety of both groups were observed before and after treatment. Results： The effective rate of TCM pattern in therapeutic group and control group was 86.67% and 80.0%. The effective rate of therapy groups was better than that of the control group（P〈0.05）. The therapy group in integral points（Lee＇s）was better than that of the control group after treatment（P〈0.05）. LVSD was decreased while LVEF was increased obviously in both groups after treatment. The decrease in LVSD and increase in LVEF of therapy group were significantly obvious than those in the control group（P〈0.05）. The level of NT-proBNP in both groups after treatment was lower than that was before treatment（P〈0.05）. The therapy groups was better than the control group in the level of NT-proBNP（P〈0.05）. Conclusion： Anxin granule has significant clinical effect in treating chronic heart failure.