包头地区抗结核药品治疗过程中不良反应研究分析

Research analysis of adverse reaction of antituberculosis drugs during treatment in Baotou area

目的了解包头地区抗结核药物不良反应的发生情况,评价不良反应对结核病治疗效果的影响。方法采用现况研究方法,对包头市某医院住院的患者进行调查。结果调查人群抗结核药物不良反应发生率为13.98%,其中肝损害发生率最高,其次为胃肠道,不良反应发生率随着年龄增大,多数发生在抗结核治疗强化期。结论包头地区抗结核药物不良反应发生率与其他地区水平相似,其中以肝损害最为常见,是导致治疗中断和病程延长的主要原因。

Objective To understand the occurrence of adverse reaction of antituberculosis drugs in Baotou area, and to evaluate the effect of adverse reactions on the treatment effect of tuberculosis.Methods A prevalence study method was adopted to investigate the sufferers hospitalized in a certain hospital of Baotou. Results The incidence rate of ad- verse reactions of antituberculosis drugs in the investigated population was 13.98%, among which the incidence rate of liver damage was the highest, followed by the gastrointestinal tract.The incidence rate of adverse reactions increased with age, and the majority occurred in the reinforcement phase of antituberculosis treatment. Conclusion The incidence rate of adverse reactions of antituberculosis drugs in Baotou area is similar to that in other regions, with the most com- mon of liver damage, which is the main reason for treatment interruption and course prolongation.