酸化蒙脱土/氯化锌催化叔丁醚和叔丁酯的合成

Synthesis of tert-Butyl Ethers and tert-Butyl Esters Catalyzed by Acid-treated Montmorillonite Supported Zinc Chloride

以酸化蒙脱土/氯化锌作为催化剂,二碳酸二叔丁酯与一系列酚、醇和羧酸类化合物在120℃封管条件下反应,合成了叔丁醚和叔丁酯类衍生物,方法简单,经济可靠,环境友好,后处理方便,收率为61%～75%,产物结构经1H NMR,ESI-MS确证。探讨了溶剂、温度、金属离子等因素对反应收率的影响,并提出了可能的反应机理。为今后该类化合物的合成提供了一种新的方法。

With acid-treated montmorillonite supported zinc chloride （H-mont/ZnC12 ） as the catalyst, phenols, alcohols, and carboxylic acid were reacted with di-tert-butyl dicarbonate to give ten-butyl ether and tert-butyl ester derivatives at 120 ~C in sealed tube with yields ranging from 61% to 75%, which is simple and environmentally friendly. All the compounds synthesized were confirmed by 1H NMR and ESI-MS. The effect of solvent, temperature, metal ion and some other factors to the reaction were investigated. A possible mechanism for this reaction was proposed. Provided a new method for this type of synthesis in the future.