自体血混合曲安奈德、IL-2、利多卡因联合斑秃丸治疗斑秃的疗效

Effect of autologous blood mixed with triamcinolone acetonide,interleukin-2 and lidocaine focal sealing combined with oral administration of Alopecia Areata Pill for treatment of alopecia areata

目的探讨自体血加曲安奈德、白细胞介素-2（IL-2）、利多卡因局部封闭注射联合斑秃丸治疗斑秃的疗效。方法治疗组62例采用自体血（2mL）加曲安奈德（第1～4周剂量递减，分别为25、20、15、10mg）、IL-2（20万单位）、2％利多卡因（2mL）组成“混合液”皮损处局部封闭注射，每周1次，共4周；对照1组53例采用自体血（2mL）加IL-2（20万单位）、2％利多卡因（2mL）组成“混合液”皮损处局部封闭注射，每周1次，共4周；对照2组51例采用自体血（2mL）加2％利多卡因（2mL）组成“混合液”皮损处局部封闭注射，每周1次，共4周。3组患者均同时给予斑秃丸旱、中、晚各20粒（10g）口服，以4周为1个疗程。结果治疗组痊愈率为54．84％，总有效率为93．55％，对照1组痊愈率为35．85％，总有效率为73．58％，对照2组痊愈率为27．45％，总有效率为54．90％。治疗组和对照1组痊愈率、总有效率比较差异有统计学意义（X2=4．417，P=0．042；X2=8．626，P=0．003）；治疗组和对照2组痊愈率、总有效率比较，差异有统计学意义（X2=8．590，P=0．003；X2=22．98，P=0．000）；对照1组和对照2组痊愈率比较，差异无统计学意义（X2=0．846，P=0．358），总有效率比较，差异有统计学意义（X2=3．958，P=0．047）。结论自体血加曲安奈德、IL-2、利多卡因局部封闭注射联合斑秃丸治疗斑秃疗效满意，无明显不良反应。

Objective To investigate the autologous blood mixed with triamcinolone acetonide,interleukin-2（IL-2） and lidocaine local sealing combined with oral administration of Alopecia Areata Pill for the treatment of alopecia areata and its effect. Meth- ods The treatment group （ 62 cases） was treated by the mixed solution of autologous blood （2 mL） added with triamcinolone acetonide （doses were decrease progressively to 25,20,15,10 mg） ,IL-2 （20 0000 units） and 2% lidocaine （2 mL） with local sealing at the skin lesion,once per week for 4 weeks. The control group 1 （53 cases） was treated by the mixed solution of autologous blood （2 mL） added with IL-2 （20 0000 units） and 2% lidocaine （2 mL） with local sealing at the skin lesion,once per week for 4 weeks;the control group 2（51 cases） the mixed solution of autologous blood （2 mL） added with and 2% lidocaine （2 mL） with local sealing at the skin lesion, once per week for 4 weeks. The three groups simultaneously took oral Alopecia Areata Pill, each 20 pills at morning,noon and night,with 4 weeks as 1 treatment course. Results The cure rate of the treatment group was 54.84% and the total effective rate was 93.55%, which in the control group 1 and 2 were 35.85%, 73.58% and 27.45 %,54.90% respectively, the cure rate and the total effective rate had statistical difference between the treatment group and the control group 1 （X2=4. 417 ,P= 0. 042 ; X2 = 8. 626 ,P= 0. 003） ;the cure rate and the total effective rate had statistical differences between the treatment group and the control group 2（X2=8. 590,P=0. 003;X2 =22.98,P=0. 000）. Conclusion Autologous blood added with triamcinolone acetonide,IL-2 and lidocaine local sealing combined with oral Alopecia Areata Pill for the treatment of alopecia areata has satisfactory effect without obvious adverse reactions. [-