儿童李斯特菌脑炎两例

Two Cases of Listeria monocytogenes Meningitis in Children

本研究通过回顾性分析2例诊断为LM脑膜炎患儿的临床资料,总结两例儿童单核细胞增多性李斯特菌(LM)脑膜炎的临床特点及治疗转归。此两例患儿以发热、头痛、呕吐起病,脑脊液培养均为LM生长,早期经头孢类药物抗感染治疗无效,换用氨苄青霉素联合效果显著。LM脑膜炎在免疫功能正常儿童发生率低,但病死率及后遗症发生率高。发病多以发热、呕吐、头痛为主要临床表现,使用氨苄青霉素效果较好,脑脊液培养有助于诊断。

Through retrospective analysis of clinical data of 2 children who have been diagnosed as LM meningitis, the clinical characteristics and treatment outcome of two children with Lester’s meningitis（LM） were summarized. The clinical manifestation of our two cases started with headache, fever and vomit. Cerebrospinal fluid culture were LM. There was no effect by cephalosporins at the early stage. But using aminobenzylpenicillin combined meropenem responded well. The incidence on children whose immune system were normal was low,but the morbidity and mortality were high. The clinical manifestation was headache, fever and vomit. Treatment with aminobenzylpenicillin responded well. Cerebrospinal fluid culture would help to diagnosis.