阿托伐他汀短期强化治疗对急性冠状动脉综合征患者介入治疗效果及心功能的影响

Effect of short-term intensive atorvastatin treatment on interventional treatment effect and cardiac function of patients with acute coronary syndrome

目的：研究阿托伐他汀短期强化治疗对急性冠状动脉综合征患者介入治疗效果及心功能的影响。方法：对2014年5月～2015年11月期间在四川省德阳市人民医院急诊接受PCI治疗的104例急性冠脉综合征患者进行回顾性分析,根据阿托伐他汀治疗方案不同分为强化组和常规组,比较两组患者的生化指标、心超指标以及炎症反应指标。结果：强化组患者的血清TG、TC、LDL-C、hs-CRP、LDH、aHBDH、CK、CK-MB含量含量显著低于常规组,HDL-C含量高于常规组;强化组患者的E/A比值、LVEF均高于常规组,Tei指数、收缩指数、舒张指数均低于常规组;强化组患者外周血中TLR4、NF-kB的表达量以及血清中TNF-α、IL-6的含量显著低于常规组。结论：阿托伐他汀短期强化治疗对急性冠脉综合征患者介入治疗的效果具有改善作用,能够减轻心肌损伤、改善心脏舒缩功能、抑制TLR4/NFkB所介导的炎症反应。

Objective：To study the effect of short-term intensive atorvastatin treatment on interventional treatment effect and cardiac function of patients with acute coronary syndrome.Methods：A total of 104 cases with acute coronary syndrome who received PCI treatment in Emergency Department of our hospital from May 2014 to November 2015 were retrospectively analyzed and divided into intensive group and routine group according to different atorvastatin treatment methods,and then biochemical indexes,cardiac ultrasound indicators and inflammatory indexes of two groups were compared.Results：Serum TG,TC,LDL-C,hs-CRP,LDH,a-HBDH,CK and CK-MB content of intensive group were significantly lower than those of routine group while HDL-C content was higher than that of routine group;E/A ratio and LVEF of intensive group were higher than those of routine group while Tei index,systolic index and diastolic index were lower than those of routine group;TLR4and NF-kB expression levels in peripheral blood as well as TNF-αand IL-6content in serum of intensive group were significantly lower than those of routine group.Conclusions：Short-term intensive atorvastatin treatment improves the interventional treatment effect of patients with acute coronary syndrome,and can reduce myocardial injury,improve cardiac diastolic and systolic function and inhibit the inflammation mediated by TLR4/NF-kB.